Ramabadran K
Eur J Pharmacol. 1984 Mar 2;98(3-4):425-7. doi: 10.1016/0014-2999(84)90292-9.
The administration of a kappa agonist, U- 50488H produced reduction in jumping latencies in the hot plate test in Swiss and CBA strains of mice but not in CXBH , CXBK and C57BL strains. The hyperalgesia following U- 50488H in Swiss and CBA strains might possibly be related to the antagonism of endogenous substrates for kappa receptors released during the thermonociceptive stimuli. A detailed time-course study in Swiss Strain revealed that a significant hyperalgesia was observable from 10 min up to 2 h. The present results indicate that CXBH , CXBK and C57BL strains might be deficient in kappa ligands and/or receptor levels relevant to thermonociception .
给予κ激动剂U - 50488H可使瑞士小鼠和CBA小鼠品系在热板试验中的跳跃潜伏期缩短，但对CXBH、CXBK和C57BL小鼠品系则无此作用。瑞士小鼠和CBA小鼠品系在给予U - 50488H后出现的痛觉过敏可能与热伤害性刺激期间释放的κ受体内源性底物的拮抗作用有关。对瑞士小鼠品系进行的详细时程研究表明，从10分钟到2小时可观察到明显的痛觉过敏。目前的结果表明，CXBH、CXBK和C57BL小鼠品系可能缺乏与热伤害感受相关的κ配体和/或受体水平。
