Efimov V V, Blazhko V I, Liashenko M M, Voeĭkova L S, Bondar' T N
Ter Arkh. 1991;63(3):70-3.
A study was made of the effect of ketotifen on the concentration of leukotriene B4, prostacyclin and thromboxane A2 in the liquid of bronchoalveolar lavage and on external respiration and cellular immunity during 4 weeks of the treatment of patients with infection-dependent bronchial asthma and chronic obstructive bronchitis. Inclusion of ketotifen into the treatment of patients with bronchial obstruction exerts a stimulating action on the suppressor component of T-cell immunity, leads to a decrease of the content of leukotriene B4 and thromboxane A2 in the lavage liquid, which is accompanied by positive shifts in the clinical course of the broncho-obstructive syndrome. Ketotifen turned out most effective in patients with an initially low content of the subpopulation of T suppressors and with high concentrations of leukotriene B4 and thromboxane A2 in the liquid of bronchoalveolar lavage.
对酮替芬在感染相关性支气管哮喘和慢性阻塞性支气管炎患者治疗4周期间，对支气管肺泡灌洗液体中白三烯B4、前列环素和血栓素A2浓度以及对外呼吸和细胞免疫的影响进行了研究。将酮替芬纳入支气管阻塞患者的治疗中，对T细胞免疫的抑制成分有刺激作用，导致灌洗液体中白三烯B4和血栓素A2含量降低，这伴随着支气管阻塞综合征临床病程的积极变化。酮替芬在最初T抑制细胞亚群含量低且支气管肺泡灌洗液体中白三烯B4和血栓素A2浓度高的患者中最为有效。
