Efimov V V, Blazhko V I, Voeĭkdova L S, Liashenko M M, Bondar' T N
Klin Med (Mosk). 1991 May;69(5):63-5.
The addition of ketanserin (a blocker of serotonin S2-receptors) to treatment of bronchial obstruction is shown to lower plasma and platelet concentrations of serotonin, leukotriene B4 level in the lavage fluid, to shift prostacyclin-thromboxane balance to the side of prostacyclin. In 40 patients with chronic obstructive bronchitis treated, the above changes were associated with persistent clinical response, a decrease of bronchial obstruction, being the most profound in a group of patients with chronic catarrhal bronchitis.
在支气管阻塞治疗中添加酮色林（一种血清素S2受体阻滞剂）可降低血清素的血浆和血小板浓度、灌洗液中的白三烯B4水平，并使前列环素-血栓素平衡向前列环素一侧偏移。在接受治疗的40例慢性阻塞性支气管炎患者中，上述变化与持续的临床反应相关，即支气管阻塞减轻，在慢性卡他性支气管炎患者组中最为显著。
