从三叶鱼藤种子中提取的两种不寻常的鱼藤酮衍生物，7a - O - 甲基 - 12a - 羟基去甲鱼藤醇和螺 - 13 - 高 - 13 - 氧杂椭圆酮。

Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo-13-oxaelliptone, from the seeds of Derris trifoliata.

作者信息

Yenesew Abiy, Kiplagat John T, Derese Solomon, Midiwo Jacob O, Kabaru Jacques M, Heydenreich Matthias, Peter Martin G

机构信息

Department of Chemistry, University of Nairobi, P.O. Box 30197, Nairobi, Kenya.

出版信息

Phytochemistry. 2006 May;67(10):988-91. doi: 10.1016/j.phytochem.2006.01.002. Epub 2006 Feb 17.

DOI:10.1016/j.phytochem.2006.01.002

PMID:16483619

Abstract

The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named spiro-13-homo-13-oxaelliptone), were isolated and characterised. In addition a rare natural chromanone (6,7-dimethoxy-4-chromanone) and the known rotenoids rotenone, tephrosin and dehydrodeguelin were identified. The structures were assigned on the basis of spectroscopic evidence. The larvicidal activity of the crude extract is mainly due to rotenone.

摘要

鱼藤的种子粗甲醇提取物对埃及伊蚊的二龄幼虫显示出强效且剂量依赖性的杀幼虫活性。从该提取物中分离并鉴定出两种不寻常的鱼藤酮类衍生物，一种鱼藤醇类化合物（命名为7a - O - 甲基 - 12a - 羟基鱼藤醇）和一种螺高氧杂类胡萝卜素（命名为螺 - 13 - 高 - 13 - 氧杂椭圆酮）。此外，还鉴定出一种罕见的天然色满酮（6,7 - 二甲氧基 - 4 - 色满酮）以及已知的鱼藤酮类化合物鱼藤酮、灰叶素和脱氢鱼藤素。这些结构是根据光谱证据确定的。粗提取物的杀幼虫活性主要归因于鱼藤酮。