Department of Pharmacy, Medical College, Hunan Normal University, Changsha 410006, China.
Molecules. 2012 Jan 11;17(1):657-63. doi: 10.3390/molecules17010657.
A new flavanone, 4',5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro-rotenone, dehydrodeguelin, 7a-O-methyldeguelol, 7a-O-methylelliptonol, 5,7,3',4'-tetra-hydroxy-6,8-diprenylisoflavone, daidzein and 4'-hydroxy-7-methoxyflavanone. 7a-O-Methylelliptonol was isolated for the first time from the genus Derris. Their structures were characterized on the basis of spectral data. Eight of the isolated compounds were found to be significantly toxic to brine shrimp (LC(50) range 0.06-9.95 μg/mL). The new compound showed weak toxicity (LC(50) = 211.31 μg/mL).
从三裂叶鱼藤的地上部分分离得到一个新的黄烷酮，4',5,7-三羟基-6,8-二-(2-羟基-3-甲基-2-丁烯基）黄烷酮，此外还分离得到了 11 个已知化合物：鱼藤酮、美登木素、12a-羟基鱼藤酮、去氢钩吻素甲、6a,12a-脱氢鱼藤酮、去氢钩吻素甲、7a-O-甲基去氢钩吻素甲、7a-O-甲基埃里托醇、5,7,3',4'-四羟基-6,8-二戊烯基异黄酮、大豆黄素和 4'-羟基-7-甲氧基黄烷酮。7a-O-甲基埃里托醇是首次从鱼藤属植物中分离得到的。根据光谱数据对它们的结构进行了表征。分离得到的 8 种化合物对卤虫（LC（50）范围为 0.06-9.95μg/mL）具有显著毒性。新化合物表现出较弱的毒性（LC（50）=211.31μg/mL）。
