基于片段的新型肌苷-5'-单磷酸脱氢酶吲哚抑制剂：合成与初步构效关系
Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.
作者信息
Beevers Rebekah E, Buckley George M, Davies Natasha, Fraser Joanne L, Galvin Francis C, Hannah Duncan R, Haughan Alan F, Jenkins Kerry, Mack Stephen R, Pitt William R, Ratcliffe Andrew J, Richard Marianna D, Sabin Verity, Sharpe Andrew, Williams Sophie C
机构信息
UCB Celltech, Granta Park, Great Abington, Cambridge, CB1 6GS, UK.
出版信息
Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. doi: 10.1016/j.bmcl.2006.01.090. Epub 2006 Feb 17.
The elaboration of previously reported indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II, PBMC proliferation and physicochemical properties are discussed.
本文描述了将先前报道的吲哚片段开发为肌苷单磷酸脱氢酶（IMPDH）抑制剂的过程。讨论了其合成方法、对IMPDH II的体外抑制值、外周血单核细胞增殖情况以及理化性质。
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