Gallivan Steve, Utley Martin, Pagano Domenico, Treasure Tom
Clinical Operational Research Unit, University College London, UK.
Eur J Cardiothorac Surg. 2006 Apr;29(4):431-3. doi: 10.1016/j.ejcts.2005.12.057. Epub 2006 Feb 17.
We set out to develop a method for assessing the performance of clinical risk models over the spectrum of risks and to assess the performance of the EuroSCORE risk model used in cardiac surgery.
We developed a graphical method for assessing the performance of clinical risk models over the spectrum of risks. To illustrate the technique, we analysed retrospective data concerning 9268 patients that underwent cardiac surgery and for whom both the additive EuroSCORE prediction of risk of morality and vital status at 30 days were available.
The graphical tool developed, called MADCAP (Mean Adjusted Deaths Compared Against Predictions), can be used to highlight systematic features of the performance of a clinical risk model. Its use in the current study indicates that the additive version of the EuroSCORE model seems to underestimate risk amongst low-risk cases (0% and 1%). Otherwise the score systematically favours risk avoiding behaviour as the risk model underestimates mortality for 2--6% prediction but not at 7% and above.
The robustness of case-mix adjusted audit is dependent on the performance of the risk scoring system over the entire spectrum of risk. If we are to use risk adjustment of mortality rates when comparing outcomes obtained by different units or individual surgeons, it is essential that we continually review the performance of the risk adjustment method. The MADCAP method presented here provides a useful tool to this end.
我们着手开发一种方法,用于评估临床风险模型在整个风险范围内的性能,并评估心脏手术中使用的欧洲心脏手术风险评估系统(EuroSCORE)风险模型的性能。
我们开发了一种图形方法,用于评估临床风险模型在整个风险范围内的性能。为说明该技术,我们分析了9268例接受心脏手术患者的回顾性数据,这些患者均有欧洲心脏手术风险评估系统(EuroSCORE)对死亡风险的相加预测值以及30天时的生命状态数据。
所开发的名为MADCAP(Mean Adjusted Deaths Compared Against Predictions,平均调整死亡数与预测值比较)的图形工具,可用于突出临床风险模型性能的系统性特征。在本研究中的应用表明,欧洲心脏手术风险评估系统(EuroSCORE)模型的相加版本在低风险病例(0%和1%)中似乎低估了风险。否则,该评分系统系统性地倾向于风险规避行为,因为风险模型在预测死亡率为2%-6%时低估了死亡率,但在7%及以上时并非如此。
病例组合调整后的审计稳健性取决于风险评分系统在整个风险范围内的性能。如果我们在比较不同单位或个体外科医生获得的结果时使用死亡率的风险调整,那么我们必须持续审查风险调整方法的性能。本文介绍的MADCAP方法为此提供了一个有用的工具。