Grant S W, Grayson A D, Jackson M, Au J, Fabri B M, Grotte G, Jones M, Bridgewater B
University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester M23 9LT, UK.
Heart. 2008 Aug;94(8):1044-9. doi: 10.1136/hrt.2006.110478. Epub 2007 Nov 1.
To compare implications of using the logistic EuroSCORE and a locally derived model when analysing individual surgeon mortality outcomes.
Retrospective analysis of prospectively collected data.
All NHS hospitals undertaking adult cardiac surgery in northwest England.
14,637 consecutive patients, April 2002 to March 2005.
We have compared the predictive ability of the logistic EuroSCORE (uncalibrated), the logistic EuroSCORE calibrated for contemporary performance and a locally derived logistic regression model. We have used each to create risk-adjusted individual surgeon mortality funnel plots to demonstrate high mortality outcomes.
There were 458 (3.1%) deaths. The expected mortality and receiver operating characteristic (ROC) curve values were: uncalibrated EuroSCORE -5.8% and 0.80, calibrated EuroSCORE -3.1% and 0.80, locally derived model -3.1% and 0.82. The uncalibrated EuroSCORE plot showed one surgeon to have mortality above the northwest average, and no surgeon above the 95% control limit (CL). The calibrated EuroSCORE plot and the local model showed little change in surgeon ranking, but significant differences in identifying high mortality outcomes. Two of three surgeons above the 95% CL using the calibrated EuroSCORE revert to acceptable outcomes when the local model is applied but the finding is critically dependent on the calibration coefficient.
The uncalibrated EuroSCORE significantly overpredicted mortality and is not recommended. Instead, the EuroSCORE should be calibrated for contemporary performance. The differences demonstrated in defining high mortality outcomes when using a model built for purpose suggests that the choice of risk model is important when analysing surgeon mortality outcomes.
比较在分析个体外科医生的死亡率结果时,使用逻辑回归欧洲心脏手术风险评估系统(EuroSCORE)和本地衍生模型的影响。
对前瞻性收集的数据进行回顾性分析。
英格兰西北部所有进行成人心脏手术的国民保健服务(NHS)医院。
2002年4月至2005年3月期间连续的14637例患者。
我们比较了逻辑回归欧洲心脏手术风险评估系统(未校准)、针对当代表现校准后的逻辑回归欧洲心脏手术风险评估系统和本地衍生的逻辑回归模型的预测能力。我们使用每个模型创建风险调整后的个体外科医生死亡率漏斗图,以展示高死亡率结果。
有458例(3.1%)死亡。预期死亡率和受试者工作特征(ROC)曲线值分别为:未校准的欧洲心脏手术风险评估系统-5.8%和0.80,校准后的欧洲心脏手术风险评估系统-3.1%和0.80,本地衍生模型-3.1%和0.82。未校准的欧洲心脏手术风险评估系统图显示有一位外科医生的死亡率高于西北部平均水平,没有外科医生高于95%控制界限(CL)。校准后的欧洲心脏手术风险评估系统图和本地模型显示外科医生排名变化不大,但在识别高死亡率结果方面存在显著差异。使用校准后的欧洲心脏手术风险评估系统高于95%CL的三位外科医生中有两位在应用本地模型时恢复到可接受的结果,但这一发现严重依赖于校准系数。
未校准的欧洲心脏手术风险评估系统显著高估了死亡率,不建议使用。相反,欧洲心脏手术风险评估系统应针对当代表现进行校准。在使用专门构建的模型定义高死亡率结果时所显示的差异表明,在分析外科医生死亡率结果时,风险模型的选择很重要。