K-ras的历程

The odyssey of k-ras.

作者信息

Feig Larry A

机构信息

Department of Biochemistry, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

出版信息

Mol Cell. 2006 Feb 17;21(4):447-9. doi: 10.1016/j.molcel.2006.02.002.

DOI:10.1016/j.molcel.2006.02.002

PMID:16483924

Abstract

A mechanism that regulates K-Ras signaling specificity by altering its subcellular location is presented by Bivona et al. (2006). Phosphorylation of its membrane-anchoring domain by PKC drives K-Ras off of the plasma membrane and onto the outer mitochondrial membrane where it induces cell death.

摘要

比沃纳等人（2006年）提出了一种通过改变K-Ras的亚细胞定位来调节其信号特异性的机制。蛋白激酶C（PKC）对其膜锚定结构域的磷酸化作用促使K-Ras从质膜脱离，转移到线粒体外膜上，在那里它会诱导细胞死亡。