Wildner-Christensen Mette, Hansen Jane Møller, De Muckadell Ove B Schaffalitzky
Department of Med. Gastroenterology, S, Odense University Hospital, Odense, Denmark.
Scand J Gastroenterol. 2006 Feb;41(2):149-54. doi: 10.1080/00365520510024070.
Dyspepsia, a common condition in the community, affects quality of life and imposes costs on both the individual and the community. Several factors including Helicobacter pylori, acetylic salicylic acid (ASA)/non-steroidal anti-inflammatory drugs (NSAIDs) use, low-dose ASA use, alcohol consumption, cigarette smoking and social status might be responsible.
A cross-sectional study from the inclusion (intervention group) of a general population study evaluating rates of dyspepsia after H. pylori screening and eradication was carried out. A total of 10,007 individuals aged 40-64 years received questionnaires and an invitation to take part in H. pylori screening. Information on dyspepsia (the gastrointestinal symptom rating scale (GSRS) and "most bothersome symptom"), use of ASA/NSAIDs, use of low-dose ASA, lifestyle factors and level of education and employment status was obtained from the questionnaire. Dyspepsia was defined as a score of =2 in the GSRS dimension abdominal pain syndrome (aps), allowing for a maximum of one light problem score in any of the 3 items in the dimension to be overlooked.
In all, 5749/10,007 individuals participated in the study; 24.9% reported dyspepsia. In a multiple logistic regression analysis H. pylori infection was found to be a risk factor for dyspepsia, odds ratio (OR) 1.21 (CI; 1.03-1.42). However, the highest ORs for dyspepsia were: for daily use of ASA/NSAIDs 2.33 (CI; 1.72-3.15), unemployment 2.18 (CI; 2.86-2.56) and cigarette smoking =20 g/day 1.55 (CI; 1.29-1.86).
H. pylori infection is a significant risk factor for dyspepsia although of less importance than ASA/NSAIDs use, unemployment and heavy smoking.
消化不良是社区中的常见病症，会影响生活质量，并给个人和社区带来经济负担。多种因素可能与此有关，包括幽门螺杆菌、使用乙酰水杨酸（ASA）/非甾体抗炎药（NSAIDs）、使用低剂量ASA、饮酒、吸烟以及社会地位。
开展了一项横断面研究，该研究来自一项普通人群研究的纳入部分（干预组），评估幽门螺杆菌筛查和根除后的消化不良发生率。共有10007名年龄在40 - 64岁的个体收到问卷并受邀参加幽门螺杆菌筛查。通过问卷获取了有关消化不良（胃肠道症状评分量表（GSRS）和“最困扰症状”）、ASA/NSAIDs的使用、低剂量ASA的使用、生活方式因素以及教育水平和就业状况的信息。消化不良被定义为GSRS维度腹痛综合征（aps）得分≥2分，该维度的3个项目中最多允许有1个轻度问题得分被忽略。
总共5749/10007名个体参与了研究；24.9%的人报告有消化不良。在多元逻辑回归分析中，发现幽门螺杆菌感染是消化不良的一个风险因素，比值比（OR）为1.21（置信区间；1.03 - 1.42）。然而，消化不良的最高OR值分别为：每日使用ASA/NSAIDs为2.33（置信区间；1.72 - 3.15），失业为2.18（置信区间；2.86 - 2.56），每天吸烟≥20克为1.55（置信区间；1.29 - 1.86）。
幽门螺杆菌感染是消化不良的一个重要风险因素，尽管其重要性低于ASA/NSAIDs的使用、失业和重度吸烟。
