Seid Abdurahaman, Tamir Zemenu, Demsiss Wondmagegn
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Po. Box 1145, Dessie, Ethiopia.
Department of Medical Laboratory Sciences, College of Health Sciences, School of Allied Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
BMC Gastroenterol. 2018 Jan 18;18(1):13. doi: 10.1186/s12876-017-0723-5.
Dyspepsia is a common problem in the community and clinical practice with symptom(s) considered arising from the gastroduodenal region. Dyspepsia burden and associated factors vary from country to country. The aim of this study was to determine the prevalence of uninvestigated dyspepsia (UD) using Rome III criteria, associated risk factors and self-reported dyspepsia symptoms' correlation with H. pylori infection.
A cross-sectional study was conducted among randomly selected 318 out patients with gastrointestinal complaints during the period from September 1 to December 30, 2015. All patients completed a questionnaire for collecting data regarding sociodemographic, lifestyle and functional gastrointestinal disorders. Diagnosis of dyspepsia was made according to the Rome III criteria. H. pylori infection was assessed using stool antigen test. SPSS version 20.0 statistical software package was used for data analysis.
From a total of 318 patients, 48.4% had UD according to Rome III criteria; with 42.1% symptoms of epigastric pain/burning, 26.1% postprandial fullness and 22.6% early satiation. Epigastric pain/burning (AOR = 1.92, 95% CI 1.07-3.43), early satiation (AOR = 2.68, 95% CI 1.38-5.20) and belching (AOR = 4.7, 95% CI 1.54-14.40) were significantly correlated with H. pylori infection. H. pylori infection (AOR = 4.33, 95% CI 2.41-7.76) and aspirin/NSAIDs consumption (AOR = 5.29, 95% CI 2.82-9.93) were independent risk factors for UD. However, consumption of raw fruits/ vegetables at least once a week (AOR = 0.48, 95% CI 0.24-0.98) and taking two or more cups of tea a day (AOR = 0.339, 95% CI 0.17-0.70) were inversely associated with UD.
UD is highly prevalent among adults with gastrointestinal complaints. H. pylori infection is significantly associated with UD and correlates with its symptoms. Individuals with epigastric pain/burning, early satiation and belching should be primary focus of H. pylori infection diagnosis and treatment. The role of consumption of tea, raw fruits and vegetables on dyspepsia needs further large scale study.
消化不良是社区和临床实践中的常见问题，其症状被认为源于胃十二指肠区域。消化不良的负担及相关因素因国家而异。本研究的目的是使用罗马Ⅲ标准确定未经调查的消化不良（UD）的患病率、相关危险因素以及自我报告的消化不良症状与幽门螺杆菌感染的相关性。
2015年9月1日至12月30日期间，对随机选取的318例有胃肠道不适的门诊患者进行了一项横断面研究。所有患者均完成了一份问卷，以收集有关社会人口统计学、生活方式和功能性胃肠疾病的数据。根据罗马Ⅲ标准对消化不良进行诊断。使用粪便抗原检测评估幽门螺杆菌感染情况。采用SPSS 20.0统计软件包进行数据分析。
在总共318例患者中，根据罗马Ⅲ标准，48.4%患有UD；有42.1%的患者有上腹部疼痛/烧灼感症状，26.1%有餐后饱胀感，22.6%有早饱感。上腹部疼痛/烧灼感（比值比[AOR]=1.92，95%置信区间[CI] 1.07 - 3.43）、早饱感（AOR = 2.68，95% CI 1.38 - 5.20）和嗳气（AOR = 4.7，95% CI 1.54 - 14.40）与幽门螺杆菌感染显著相关。幽门螺杆菌感染（AOR = 4.33，95% CI 2.41 - 7.76）和服用阿司匹林/非甾体抗炎药（AOR = 5.29，95% CI 2.82 - 9.93）是UD的独立危险因素。然而，每周至少食用一次生水果/蔬菜（AOR = 0.48，95% CI 0.24 - 0.98）和每天饮用两杯或更多杯茶（AOR = 0.339，95% CI 0.17 - 0.70）与UD呈负相关。
UD在有胃肠道不适的成年人中高度流行。幽门螺杆菌感染与UD显著相关且与其症状相关。有上腹部疼痛/烧灼感、早饱感和嗳气的个体应成为幽门螺杆菌感染诊断和治疗的主要关注对象。茶、生水果和蔬菜的摄入对消化不良的作用需要进一步的大规模研究。
