Arora R C, Meltzer H Y
Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Biol Psychiatry. 1991 May 15;29(10):1016-22. doi: 10.1016/0006-3223(91)90358-s.
Serotonin [5-hydroxytryptamine (5-HT)]-sensitive imipramine binding (IB) was determined in the left and right hemisphere of frontal cortex of suicide victims and nonpsychiatric controls who died due to myocardial infarction or accident. The Kd (an inverse measure of affinity of 3H-imipramine to its binding sites) was significantly higher in left hemisphere than right hemisphere in normal controls. There were no differences in Bmax and Kd or Bmax between left hemisphere and right hemisphere in normals and suicides, respectively. These results do not support the finding of hemispheric asymmetry of 5-HT uptake as measured by IB (Bmax) in postmortem tissue from controls and suicide victims.
在因心肌梗死或意外事故死亡的自杀受害者和非精神科对照者的额叶皮质左、右半球中，测定了血清素[5-羟色胺（5-HT）]敏感性丙咪嗪结合（IB）。在正常对照中，左半球的Kd（3H-丙咪嗪与其结合位点亲和力的反向指标）显著高于右半球。在正常人和自杀者中，左半球和右半球之间的Bmax、Kd或Bmax分别没有差异。这些结果不支持在对照者和自杀受害者的死后组织中通过IB（Bmax）测量的5-HT摄取半球不对称性的发现。
