血管内动脉瘤栓塞用HydroCoil（HEAL）研究：围手术期结果
HydroCoil for Endovascular Aneurysm Occlusion (HEAL) study: periprocedural results.
作者信息
Cloft H J
机构信息
Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
出版信息
AJNR Am J Neuroradiol. 2006 Feb;27(2):289-92.
BACKGROUND AND PURPOSE
The HydroCoil Embolic System (HES) was developed to improve the efficacy of endovascular treatment of cerebral aneurysms. The purpose of this study is to study the periprocedural results in patients with cerebral aneurysms treated with HES.
METHODS
We report the initial periprocedural results in 191 cerebral aneurysms treated with HES in the HydroCoil for Endovascular Aneurysm Occlusion, or HEAL, study. Initial aneurysm occlusion and periprocedural complication rates were evaluated and compared with historical control data regarding aneurysms treated with platinum coils.
RESULTS
An initial occlusion result of "complete" or "near-complete" was achieved in 91.8% of aneurysms. Periprocedural thromboembolic events occurred in 8.1% of aneurysms treated with neurologic deficits related to thromboemboli occurring in 2.1% of aneurysms treated. Intraprocedural aneurysm perforations occurred in 2.8% of previously ruptured aneurysms, and in 0% of previously unruptured aneurysms.
CONCLUSION
The initial occlusion success and complication rate when HES is used to treat cerebral aneurysms is not significantly different from platinum coils. Follow-up angiography is currently being collected and will be evaluated to determine if use of the HES reduces the rate of aneurysm recurrence.
背景与目的
研发HydroCoil栓塞系统（HES）旨在提高脑动脉瘤血管内治疗的疗效。本研究的目的是探讨采用HES治疗的脑动脉瘤患者的围手术期结果。
方法
我们报告了在“用于血管内动脉瘤闭塞的HydroCoil（HEAL）”研究中191例采用HES治疗的脑动脉瘤的初始围手术期结果。评估了初始动脉瘤闭塞情况和围手术期并发症发生率，并与使用铂线圈治疗动脉瘤的历史对照数据进行比较。
结果
91.8%的动脉瘤实现了“完全”或“近乎完全”的初始闭塞结果。8.1%接受治疗的动脉瘤发生围手术期血栓栓塞事件，其中2.1%接受治疗的动脉瘤出现与血栓栓塞相关的神经功能缺损。2.8%既往破裂的动脉瘤在手术过程中发生动脉瘤穿孔，既往未破裂的动脉瘤未发生穿孔。
结论
使用HES治疗脑动脉瘤时的初始闭塞成功率和并发症发生率与铂线圈无显著差异。目前正在收集随访血管造影资料，并将进行评估以确定使用HES是否能降低动脉瘤复发率。
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