Wang Lu, Liu Simin, Manson Joann E, Gaziano J Michael, Buring Julie E, Sesso Howard D
Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
J Nutr. 2006 Mar;136(3):620-5. doi: 10.1093/jn/136.3.620.
Lycopene is a major carotenoid with potent antioxidant properties that may provide protection against the development of type 2 diabetes mellitus (DM). In this study we examined the association between baseline dietary intakes of lycopene, lycopene-containing foods, and the subsequent development of type 2 DM in a large prospective cohort study. We analyzed a total of 35,783 women from the United States, aged > or =45 y and free from self-reported cardiovascular disease, cancer, and DM at baseline. Intakes of lycopene and total and individual tomato-based food products were assessed by a 131-item-validated semiquantitative food-frequency questionnaire. During a median follow-up of 10.2 y, 1544 cases of incident type 2 DM were documented. After adjusting for age, total energy intake, randomized treatment assignment, body mass index, and other known DM risk factors, the multivariate-adjusted relative risks and 95% CI of type 2 DM across increasing quintiles of dietary lycopene, were 1.00 (baseline), 1.10 (0.94-1.29), 1.10 (0.94-1.29), and 1.07 (0.91-1.26) (P linear trend = 0.56). Compared with women who consumed <1.5 servings/wk total tomato-based food products, women who consumed 1.5 to <4, 4 to <7, 7 to <10, and > or =10 servings/wk had multivariate relative risks (95% CI) of 1.03 (0.88-1.20), 1.02 (0.87-1.20), 1.09 (0.89-1.33), and 1.04 (0.80-1.36), respectively (P linear trend = 0.54). The associations for individual tomato-based food products were similar to the results for the combination of all tomato products. Our study found little evidence for an association between dietary intake of lycopene or lycopene-containing foods and the risk of type 2 DM.
番茄红素是一种具有强大抗氧化特性的主要类胡萝卜素，可能对2型糖尿病（DM）的发生发展具有保护作用。在本研究中，我们在一项大型前瞻性队列研究中，探讨了番茄红素、含番茄红素食物的基线饮食摄入量与随后2型DM发生之间的关联。我们分析了来自美国的总共35783名年龄≥45岁且基线时无自我报告心血管疾病、癌症和DM的女性。通过一份经过131项验证的半定量食物频率问卷评估番茄红素以及各类以番茄为基础的食品的总摄入量和个体摄入量。在中位随访10.2年期间，记录了1544例2型DM新发病例。在调整年龄、总能量摄入量、随机治疗分配、体重指数和其他已知的DM风险因素后，随着饮食中番茄红素五分位数的增加，2型DM的多变量调整相对风险及95%CI分别为1.00（基线）、1.10（0.94 - 1.29）、1.10（0.94 - 1.29）和1.07（0.91 - 1.26）（P线性趋势 = 0.56）。与每周食用少于1.5份以番茄为基础的食品的女性相比，每周食用1.5至少于4份、4至少于7份、7至少于10份以及≥10份的女性的多变量相对风险（95%CI）分别为1.03（0.88 - 1.20）、1.02（0.87 - 1.20）、1.09（0.89 - 1.33）和1.04（0.80 - 1.36）（P线性趋势 = 0.54）。各类以番茄为基础的食品的关联结果与所有番茄制品组合的结果相似。我们的研究几乎没有发现饮食中番茄红素或含番茄红素食物的摄入量与2型DM风险之间存在关联的证据。
