Food Technology Program, School of Industrial Technology, Universiti Sains Malaysia, Gelugor 11800, Pulau Pinang, Malaysia.
Molecules. 2022 Apr 4;27(7):2335. doi: 10.3390/molecules27072335.
Nutrition is of utmost importance in chronic disease management and has often been described as the cornerstone of a variety of non-communicable diseases. In particular, type II diabetes mellitus (T2DM) represents a prevalent and global public health crisis. Lycopene, a bright red carotenoid hydrocarbon found in tomatoes and other red fruits and vegetables, has been extensively studied for its biological activities and treatment efficiency in diabetes care. Epidemiological investigations indicate that lycopene has potential antioxidant properties, is capable of scavenging reactive species, and alleviates oxidative stress in T2DM patients. This review aims to summarize the characteristics and mechanisms of action of lycopene as a potent antioxidant for T2DM. In addition, the evidence demonstrating the effects of lycopene on glycemic control and oxidative stress biomarkers in T2DM are also highlighted using animal and human studies as literature approach.
营养在慢性病管理中至关重要，常常被描述为多种非传染性疾病的基石。特别是，2 型糖尿病（T2DM）是一种普遍存在且全球性的公共健康危机。番茄红素是一种存在于番茄和其他红色水果和蔬菜中的亮红色类胡萝卜素碳氢化合物，因其在糖尿病治疗中的生物活性和治疗效果而得到广泛研究。流行病学调查表明，番茄红素具有潜在的抗氧化特性，能够清除活性物质，减轻 T2DM 患者的氧化应激。本综述旨在总结番茄红素作为一种有效的抗氧化剂治疗 T2DM 的特点和作用机制。此外，还通过动物和人体研究作为文献方法，强调了番茄红素对 T2DM 患者血糖控制和氧化应激生物标志物的影响。
