Gail Mitchell H, You Wei-Cheng
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
J Nutr. 2006 Mar;136(3 Suppl):813S-815S. doi: 10.1093/jn/136.3.813S.
The Shandong Intervention Trial was a factorial, double-blind, placebo-controlled trial to determine whether any of 3 interventions, alone or in combination, could reduce the prevalence of precancerous gastric lesions in Linqu County, Shandong Province, China, a region with high gastric cancer mortality rates and a prevalence in adults of Helicobacter pylori of approximately 67%. The 3 interventions were one-time treatment with amoxicillin and omeprazole for Helicobacter pylori infection, and long-term administration of a garlic supplement (aged garlic extract and steam-distilled garlic oil) and a vitamin supplement (vitamins E and C and selenium). This paper describes the design and initial findings on treatment compliance, completeness of follow-up data, and eradication of Helicobacter pylori.
山东干预试验是一项析因、双盲、安慰剂对照试验，旨在确定三种干预措施单独或联合使用是否能降低中国山东省临朐县癌前胃部病变的患病率。临朐县胃癌死亡率高，成年人幽门螺杆菌感染率约为67%。这三种干预措施分别是：用阿莫西林和奥美拉唑一次性治疗幽门螺杆菌感染，长期服用大蒜补充剂（ aged garlic extract和蒸汽蒸馏大蒜油）和维生素补充剂（维生素E、C和硒）。本文描述了该试验的设计以及关于治疗依从性、随访数据完整性和幽门螺杆菌根除情况的初步研究结果。
