Ross Sharon A, Finley John W, Milner John A
Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, U S Department of Health and Human Services, Rockville, MD 20892-7328, USA.
J Nutr. 2006 Mar;136(3 Suppl):852S-854S. doi: 10.1093/jn/136.3.852S.
The health benefits of garlic, including inhibition of carcinogenesis, are supported by several epidemiologic and laboratory findings. Garlic's sulfur components have been reported to suppress experimentally induced tumor incidence in several organs, including the colon. Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer. Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents. In preclinical studies, both water- and lipid-soluble allyl sulfur compounds arising from processed garlic inhibited ACF. The response to these allyl sulfur compounds appears to depend on several factors, including the speciation, quantity, and duration provided.
大蒜的健康益处，包括抑制致癌作用，得到了多项流行病学和实验室研究结果的支持。据报道，大蒜中的硫成分可抑制实验诱导的多个器官（包括结肠）的肿瘤发生率。对人类的研究还表明，膳食中的大蒜成分可降低患结直肠腺瘤性息肉的风险，而结直肠腺瘤性息肉被认为是结肠癌的前兆。异常隐窝灶（ACF）被认为是人类腺瘤 - 癌以及啮齿动物化学诱导结肠癌的早期癌前病变。在临床前研究中，加工大蒜产生的水溶性和脂溶性烯丙基硫化合物均可抑制ACF。对这些烯丙基硫化合物的反应似乎取决于几个因素，包括种类、数量和提供的持续时间。
