Gharadaghi Yaghub, Shojaee Saeedeh, Khaki Arash, Hatef Amir, Ahmadi Ashtiani Hamid Reza, Rastegar Hossin, Fathiazad Fatemeh
Department of Parisitology,Tabriz Branch,Islamic Azad University, Tabriz, Iran.
Adv Pharm Bull. 2012;2(1):1-6. doi: 10.5681/apb.2012.001. Epub 2012 Feb 15.
Toxoplasma gondii is a widespread protozoan parasite that infects a broad range of warm blooded animals as well as humans. The present study was investigated to evaluate the effects of allium cepa on renal failur in male rats which experimentally infected by Toxoplasma gondii, RH strain.
Wistar male rat (n=40) were allocated into four groups, group one that received tachyzoites of T. gondii (ip) (n=10), group two that received tachyzoites of T. gondii (ip), plus fresh onion juice by gavages method (n=10), group three received just fresh onion juice by gavages method (n=10) and control group (n=10) that received nothing. Animals were kept in standard condition. In 30 day after inducing Toxoplasma infection, 5cc blood was collected for serum protein and TAC levels. Kidney tissues of Rat in whole groups were removed and prepared for apopetosis analysis.
Serum protein and kidneys weights were significantly decreased in groups that were infected with T. gondii, in comparison to control and onions groups. Kidneys Apopetosis in toxoplasma group significantly increased in comparison to control group (P<0.05).level of TAC was significantly increased in groups that received onio juice (P<0.05).
This study showed that T. gondii have significantly effect on serum protein and TAC, apopetosis and fresh onion juice returned and treated this harmful effect, so it is suggested that eating of onion is useful in toxoplasma infection.
刚地弓形虫是一种广泛传播的原生动物寄生虫，可感染多种温血动物以及人类。本研究旨在评估洋葱对实验性感染刚地弓形虫RH株的雄性大鼠肾衰竭的影响。
将40只Wistar雄性大鼠分为四组，第一组腹腔注射刚地弓形虫速殖子（n = 10），第二组腹腔注射刚地弓形虫速殖子并通过灌胃法给予新鲜洋葱汁（n = 10），第三组仅通过灌胃法给予新鲜洋葱汁（n = 10），对照组（n = 10）不给予任何处理。动物饲养在标准条件下。在诱导弓形虫感染30天后，采集5毫升血液用于检测血清蛋白和总抗氧化能力（TAC）水平。取出所有组大鼠的肾脏组织，准备进行凋亡分析。
与对照组和洋葱组相比，感染刚地弓形虫的组血清蛋白和肾脏重量显著降低。与对照组相比，弓形虫组肾脏凋亡显著增加（P < 0.05）。接受洋葱汁的组TAC水平显著升高（P < 0.05）。
本研究表明，刚地弓形虫对血清蛋白和TAC、凋亡有显著影响，新鲜洋葱汁可恢复并治疗这种有害影响，因此建议食用洋葱对弓形虫感染有益。
