当发病时间不明确时，灌注CT有助于溶栓治疗的决策制定。
Perfusion CT helps decision making for thrombolysis when there is no clear time of onset.
作者信息
Hellier K D, Hampton J L, Guadagno J V, Higgins N P, Antoun N M, Day D J, Gillard J H, Warburton E A, Baron J-C
机构信息
Department of Stroke Medicine, Addenbrooke's Hospital, Cambridge, UK.
出版信息
J Neurol Neurosurg Psychiatry. 2006 Mar;77(3):417-9. doi: 10.1136/jnnp.2005.067363.
Abstract
Current guidelines on thrombolysis post stroke with recombinant tissue plasminogen activator (rt-PA) exclude its use where time of onset is unknown, thus denying some patients potentially beneficial treatment. Contrast enhanced perfusion computed tomography (pCT) imaging can be used together with plain CT and information on clinical deficits to decide whether or not thrombolysis should be initiated even though the exact time of stroke onset is unknown. Based on the results of pCT and CT, rt-PA was administered to two patients with unknown time of stroke onset; one of the patients also underwent suction thrombectomy. Results in both cases were excellent.
摘要
目前关于使用重组组织型纤溶酶原激活剂（rt-PA）进行中风后溶栓的指南排除了在发病时间未知的情况下使用该药物，从而使一些患者无法获得可能有益的治疗。对比增强灌注计算机断层扫描（pCT）成像可与普通CT及临床缺损信息一起使用，以决定即使中风确切发病时间未知时是否应开始溶栓治疗。根据pCT和CT的结果，对两名发病时间未知的患者给予了rt-PA治疗；其中一名患者还接受了抽吸血栓切除术。两例结果均极佳。
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