来自人肝转移癌的血型N抗原前体糖蛋白和具有桑森-弗里登赖希（T）活性的N抗原前体糖蛋白。
Blood group N antigen precursor glycoproteins and N antigen precursor glycoproteins with Thomsen-Friedenreich (T) activity from human liver metastatic carcinomas.
作者信息
Otsuka K, Kudo T, Nakajima T, Ohkuma S
机构信息
Department of Biochemistry, Tokyo College of Pharmacy, Japan.
出版信息
Int J Biochem. 1991;23(5-6):569-78.
PMID:1648519
Abstract
- Four perchloric acid-soluble fractions (PASFs) from human liver metastases of sigmoid colon carcinoma (LSCC), pancreas carcinoma (LPC), breast carcinoma (LBC) and human normal liver (NL) were subjected to DEAE-cellulose column chromatography and separated into three glycoprotein fractions, respectively. 2. In chromatography, LSCC-PASF and LBC-PASF gave Thomsen-Friedenreich (T)-active glycoprotein, blood group N antigen precursor glycoprotein with T activity and N antigen precursor glycoprotein, respectively. 3. LPC-PASF gave N antigen precursor glycoprotein with T activity and two N antigen precursor glycoproteins. 4. The three glycoprotein fractions from NL-PASF did not exhibit both T activity and N antigen precursor activity.
摘要
- 对来自乙状结肠癌（LSCC）、胰腺癌（LPC）、乳腺癌（LBC）的人肝转移灶以及人正常肝脏（NL）的四种高氯酸可溶性组分（PASFs）进行了二乙氨基乙基纤维素柱色谱分析，并分别分离成三种糖蛋白组分。2. 在色谱分析中，LSCC - PASF和LBC - PASF分别产生了具有Thomsen - Friedenreich（T）活性的糖蛋白、具有T活性的血型N抗原前体糖蛋白和N抗原前体糖蛋白。3. LPC - PASF产生了具有T活性的N抗原前体糖蛋白和两种N抗原前体糖蛋白。4. NL - PASF的三种糖蛋白组分均未表现出T活性和N抗原前体活性。
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