Fong T L, Di Bisceglie A M, Waggoner J G, Banks S M, Hoofnagle J H
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Hepatology. 1991 Jul;14(1):64-7. doi: 10.1002/hep.1840140111.
We assessed the prevalence and clinical significance of antibodies to hepatitis C virus among a cohort of 148 patients with chronic hepatitis B virus infection. Sixteen patients (11%) had anti-hepatitis C virus detectable by enzyme-linked immunoassay. The results from eight of these patients were positive by recombinant immunoblot assay. The results of recombinant immunoblot assay testing were not consistent; therefore the analysis of the patients' data was based on anti-hepatitis C virus enzyme-linked immunoassay results. Patients with chronic hepatitis B with anti-hepatitis C virus were more likely to be cirrhotic (44% vs. 21%) and to have decompensated liver disease (24% vs. 6%). Hepatitis B virus replication appeared to be suppressed in patients with both infections as measured by hepatitis B virus-associated DNA polymerase activity (mean = 2,055 vs. 2,555 cpm). Human immunodeficiency virus infection was more common in the anti-hepatitis C virus positive group (36% vs. 11%). Thus hepatitis C virus appears to suppress hepatitis B virus replication and to cause more severe liver disease in patients with chronic hepatitis B infection.
我们评估了148例慢性乙型肝炎病毒感染患者队列中丙型肝炎病毒抗体的流行情况及其临床意义。16例患者（11%）通过酶联免疫吸附测定法可检测到抗丙型肝炎病毒。其中8例患者的重组免疫印迹法检测结果为阳性。重组免疫印迹法检测结果不一致；因此，患者数据的分析基于抗丙型肝炎病毒酶联免疫吸附测定结果。慢性乙型肝炎合并抗丙型肝炎病毒的患者更易发生肝硬化（44%对21%）和失代偿性肝病（24%对6%）。通过乙型肝炎病毒相关DNA聚合酶活性检测发现，两种感染患者的乙型肝炎病毒复制似乎均受到抑制（平均分别为2,055对2,555 cpm）。人类免疫缺陷病毒感染在抗丙型肝炎病毒阳性组中更为常见（36%对11%）。因此，丙型肝炎病毒似乎会抑制慢性乙型肝炎感染患者的乙型肝炎病毒复制，并导致更严重的肝病。
