丙型肝炎的自然史
Natural History of Hepatitis C.
作者信息
Lingala Shilpa, Ghany Marc G
机构信息
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B-16, 10 Center Drive, MSC 1800, Bethesda, MD 20892-1800, USA.
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B-16, 10 Center Drive, MSC 1800, Bethesda, MD 20892-1800, USA.
出版信息
Gastroenterol Clin North Am. 2015 Dec;44(4):717-34. doi: 10.1016/j.gtc.2015.07.003. Epub 2015 Aug 25.
Abstract
Hepatitis C infection is a common cause of cirrhosis and indication for liver transplantation in the United States. The incidence of chronic hepatitis C has been declining, but rates of cirrhosis and hepatocellular carcinoma are projected to increase. The outcome of chronic hepatitis C is variable. It is estimated that 20% to 25% will develop cirrhosis over a 25-year to 30-year period. The rate of disease progression is influenced by many host, viral, and environmental factors. Few can be modified.
摘要
丙型肝炎感染是美国肝硬化的常见病因及肝移植指征。慢性丙型肝炎的发病率一直在下降，但肝硬化和肝细胞癌的发病率预计将会上升。慢性丙型肝炎的预后各不相同。据估计，20%至25%的患者在25至30年的时间里会发展为肝硬化。疾病进展速度受许多宿主、病毒和环境因素影响。其中很少因素可以改变。
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