墨西哥美洲印第安人和梅斯蒂索人群中β1肾上腺素能受体多态性Arg389Gly和Ser49Gly

Beta1 adrenergic receptor polymorphisms Arg389Gly and Ser49Gly in the Amerindian and Mestizo populations of Mexico.

作者信息

Fragoso José Manuel, Rodríguez-Pérez José Manuel, Pérez-Vielma Nadia, Martínez-Rodríguez Nancy, Vargas-Alarcón Gilberto

机构信息

Department of Physiology and Grupo de Estudio en Genómica y Proteómica de Enfermedades Cardiovasculares, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Tlalpan 14080, Mexico City, Mexico.

出版信息

Hum Biol. 2005 Aug;77(4):515-20.

PMID:16485781

Abstract

The beta1 adrenergic receptor genotypes (Ser49Gly and Arg389Gly) were determined in 190 individuals from 3 Mexican populations. Mestizos and Teenek present the highest frequencies for the *Arg allele and the lowest frequencies for the *Gly allele (Arg389Gly) compared to European, Asian, and African populations. Mayos present the highest frequency for the *Gly allele. The knowledge of the distribution of these alleles could help define the significance of these polymorphisms as genetic susceptibility markers in Amerindian populations.

摘要

在来自3个墨西哥人群的190名个体中测定了β1肾上腺素能受体基因型（Ser49Gly和Arg389Gly）。与欧洲、亚洲和非洲人群相比，混血儿和特内克人*Arg等位基因频率最高，Gly等位基因（Arg389Gly）频率最低。马约人Gly等位基因频率最高。了解这些等位基因的分布有助于确定这些多态性作为美洲印第安人群遗传易感性标志物的意义。