β1肾上腺素能受体基因多态性：急性冠脉综合征中比索洛尔反应的一种可能的遗传预测指标
β1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol response in acute coronary syndrome.
作者信息
Fayed Mohamed S, Saleh Mohamed Ayman, Sabri Nagwa A, Elkholy Amal A
机构信息
Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, 1181, Egypt.
出版信息
Future Sci OA. 2023 Aug 22;9(10):FSO895. doi: 10.2144/fsoa-2023-0113. eCollection 2023 Dec.
AIM
To investigate the association between beta1-adrenergic receptor () polymorphisms and response to bisoprolol treatment in beta-blocker naive patients with acute coronary syndrome (ACS).
PATIENTS & METHODS: Seventy-seven patients received bisoprolol for four weeks. Blood pressure and heart rate were measured at baseline and during treatment. TaqMan allelic discrimination method was utilized for Ser49Gly and Arg389Gly genotyping.
RESULTS
Arg389Arg carriers showed greater reductions in systolic and diastolic blood pressure (-8.5% ± 7.8% vs -0.76% ± 8.7%, p = 0.000218), and (-9.5% ± 9.7% vs -0.80% ± 11.5%, p = 0.000149), respectively, compared with Gly389 carriers. No statistical difference was found for study's outcomes based on codon 49.
CONCLUSION
Arg389Gly polymorphism is a promising bisoprolol response predictor in ACS patients.
目的
研究β1-肾上腺素能受体（β1-AR）基因多态性与初治β受体阻滞剂的急性冠状动脉综合征（ACS）患者对比索洛尔治疗反应之间的关联。
患者与方法
77例患者接受比索洛尔治疗4周。在基线期和治疗期间测量血压和心率。采用TaqMan等位基因鉴别法对β1-AR基因第49密码子的Ser49Gly和第389密码子的Arg389Gly进行基因分型。
结果
与Gly389携带者相比，Arg389Arg携带者的收缩压和舒张压降幅更大（分别为-8.5% ± 7.8% 对 -0.76% ± 8.7%，p = 0.000218），以及（-9.5% ± 9.7% 对 -0.80% ± 11.5%，p = 0.000149）。基于第49密码子的研究结果未发现统计学差异。
结论
Arg389Gly基因多态性是ACS患者比索洛尔反应的一个有前景的预测指标。
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