Fragoso José Manuel, Rodríguez-Pérez José Manuel, González Jaime, Cruz David, Pérez-Méndez Oscar, de Jesus García José, de la Peña Aurora, Arce Minerva, Reyes Pedro A, Vargas-Alarcón Gilberto
Department of Physiology, Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan 14080, Mexico City, Mexico.
Exp Mol Pathol. 2006 Jun;80(3):279-82. doi: 10.1016/j.yexmp.2005.12.005. Epub 2006 Feb 20.
The objective of the study was to evaluate the role of beta1-adrenergic receptor gene polymorphisms (Ser49Gly and Arg389Gly) as susceptibility markers for idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The polymorphisms were analyzed in 47 patients with IDC and 93 ethnically matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism. The Ser49Gly allele and genotype frequencies were similar in patients and healthy controls. On the other hand, the analysis of the Arg389Gly polymorphism showed an increased frequencies of the *Gly allele (pC = 0.022, OR = 2.16) and *Arg/*Gly genotype (pC = 0.027, OR = 2.70) in the group of IDC patients when compared to healthy controls. The data suggest that Arg389Gly polymorphism could be involved in the genetic susceptibility to develop IDC in Mexicans.
本研究的目的是评估β1-肾上腺素能受体基因多态性（Ser49Gly和Arg389Gly）作为墨西哥患者特发性扩张型心肌病（IDC）易感性标志物的作用。通过聚合酶链反应-限制性片段长度多态性分析了47例IDC患者和93名种族匹配的健康对照者的多态性。Ser49Gly等位基因和基因型频率在患者和健康对照者中相似。另一方面，与健康对照者相比，对Arg389Gly多态性的分析显示，IDC患者组中Gly等位基因（pC = 0.022，OR = 2.16）和Arg/*Gly基因型（pC = 0.027，OR = 2.70）的频率增加。数据表明，Arg389Gly多态性可能与墨西哥人发生IDC的遗传易感性有关。
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