Perra M T, Colombari R, Maxia C, Zucca I, Piras F, Corbu A, Bravo S, Scarpa A, Sirigu P
Department of Cytomorphology, Eye Clinic, University of Cagliari, Cagliari, Italy.
Histopathology. 2006 Mar;48(4):387-93. doi: 10.1111/j.1365-2559.2006.02346.x.
Conjunctival pigmented lesions have characteristic clinical and histopathological appearances. Melanocytic pigmented lesions commonly occur in the conjunctiva, although they have not been previously reported in pterygium, a common lesion which originates from conjunctiva. Our aim was to evaluate the possibility of an association between pterygium and conjunctival melanocytic pigmented lesions.
A total of 80 samples of pterygium excised from Ecuadorian patients in 2002 were collected. Clinical data were available regarding age, sex, race and place of residence. Histological sections were evaluated for the presence of melanocytic pigmented lesions. Nine cases of conjunctival melanocytic, pigmented lesions within pterygium were found and were classified according to the histopathological criteria previously published for pigmented lesions of the conjunctiva, as naevi and primary acquired melanosis (PAM) with varying degrees of atypia. Five of the nine cases showed primary acquired melanosis without atypia, while two cases had atypia; one case showed features of compound naevus and one lesion was designated as subepithelial naevus.
Our findings suggest that conjunctival melanocytic, pigmented lesions occasionally occur in pterygium. All surgically removed pterygia should undergo careful histopathological examination.
结膜色素沉着性病变具有特征性的临床和组织病理学表现。黑素细胞性色素沉着性病变常见于结膜,尽管此前尚未在起源于结膜的常见病变翼状胬肉中报道过。我们的目的是评估翼状胬肉与结膜黑素细胞性色素沉着性病变之间存在关联的可能性。
收集了2002年从厄瓜多尔患者切除的80份翼状胬肉样本。可获得关于年龄、性别、种族和居住地的临床数据。对组织学切片进行评估,以确定是否存在黑素细胞性色素沉着性病变。在翼状胬肉中发现了9例结膜黑素细胞性色素沉着性病变,并根据先前发表的结膜色素沉着性病变的组织病理学标准,将其分类为痣和不同程度异型性的原发性获得性黑素沉着症(PAM)。9例中有5例表现为无异型性的原发性获得性黑素沉着症,2例有异型性;1例表现为复合痣特征,1个病变被指定为上皮下痣。
我们的研究结果表明,结膜黑素细胞性色素沉着性病变偶尔发生于翼状胬肉中。所有手术切除的翼状胬肉均应进行仔细的组织病理学检查。