脱落细胞学检查在色素性结膜病变中的预测价值
Predictive value of exfoliative cytology in pigmented conjunctival lesions.
作者信息
Keijser Sander, van Luijk Chantal M, Missotten Guy S, Veselic-Charvat Maud, de Wolff-Rouendaal Didi, de Keizer Rob J W
机构信息
Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands.
出版信息
Acta Ophthalmol Scand. 2006 Apr;84(2):188-91. doi: 10.1111/j.1600-0420.2005.00585.x.
PURPOSE
Pigmented lesions of the conjunctiva are often difficult to classify clinically. Exfoliative cytology may be helpful, but reliable data regarding the sensitivity and specificity of this test are currently lacking. We determined the value of exfoliative cytology with regard to pigmented conjunctival lesions.
METHODS
A total of 294 smears from 182 patients were screened for malignancy within 6 months of exfoliative cytology. Smears were classified according to the following categories: grade 0 = insufficient material for diagnosis; grade 1 = normal conjunctival cells; grade 2 = melanocytes with mild atypia; grade 3 = melanocytes with moderate atypia, and grade 4 = melanocytes with severe atypia.
RESULTS
The sensitivity, specificity, positive predictive value and negative predictive value of exfoliative cytology were 85%, 78%, 59% and 93%, respectively.
CONCLUSION
Exfoliative cytology is a fast, easy and non-invasive technique that may be used in the evaluation of patients with a pigmented conjunctival lesion.
目的
结膜色素沉着病变在临床上常常难以分类。脱落细胞学检查可能会有所帮助，但目前缺乏关于该检查敏感性和特异性的可靠数据。我们确定了脱落细胞学检查对于结膜色素沉着病变的价值。
方法
在脱落细胞学检查后的6个月内，对182例患者的总共294份涂片进行恶性肿瘤筛查。涂片根据以下类别进行分类：0级=诊断材料不足；1级=正常结膜细胞；2级=轻度异型性黑素细胞；3级=中度异型性黑素细胞，4级=重度异型性黑素细胞。
结果
脱落细胞学检查的敏感性、特异性、阳性预测值和阴性预测值分别为85%、78%、59%和93%。
结论
脱落细胞学检查是一种快速、简便且无创的技术，可用于评估结膜色素沉着病变患者。
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