Baptista T, Murzi E, Hernandez L, Burguera J L, Burguera M
Laboratorio de Fisiologia de la Conducta, Facultad de Medicina, Universidad de los Andes, Mérida, Venezuela.
Pharmacol Biochem Behav. 1991 Mar;38(3):533-7. doi: 10.1016/0091-3057(91)90009-q.
Two experiments are reported here. First, the effect of lithium chloride (1, 2 and 4 mEq/kg IP for 21 days) on body weight was assessed in female and male rats. Food intake was measured in the rats treated with 2 mEq/kg. All the doses tested significantly increased body weight in female rats. A linear relationship between body weight gain and lithium dose was also observed. In contrast, in male rats, the low doses of lithium (1 and 2 mEq/kg) did not affect body weight, whereas the high dose (4 mEq/kg) decreased body weight. These results confirm previous reports on a sex-dependent effect of lithium on body weight in rats. In the second experiment, body weight and food intake were assessed in female rats treated with lithium alone, or in combination with insulin or sulpiride, a D2 dopamine receptor blocker. It was found that the effect of lithium on body weight and feeding was additive to the effects of sulpiride and insulin. These findings are indirect evidence that lithium enhances body weight in rats by a different mechanism than the one described for sulpiride or insulin.
本文报告了两项实验。首先，评估了氯化锂（腹腔注射，剂量为1、2和4毫当量/千克，持续21天）对雌性和雄性大鼠体重的影响。对接受2毫当量/千克剂量治疗的大鼠测量了食物摄入量。所有测试剂量均显著增加了雌性大鼠的体重。还观察到体重增加与锂剂量之间存在线性关系。相比之下，在雄性大鼠中，低剂量的锂（1和2毫当量/千克）对体重没有影响，而高剂量（4毫当量/千克）则降低了体重。这些结果证实了先前关于锂对大鼠体重的性别依赖性影响的报道。在第二项实验中，评估了单独用锂治疗或与胰岛素或D2多巴胺受体阻滞剂舒必利联合治疗的雌性大鼠的体重和食物摄入量。发现锂对体重和进食的影响与舒必利和胰岛素的影响具有相加性。这些发现间接证明，锂通过与舒必利或胰岛素不同的机制增加大鼠体重。
