Baptista T, Parada M, Hernandez L
Laboratorio de Fisiologia de la Conducta Facultad de Medicina, Merida, Venezuela.
Pharmacol Biochem Behav. 1987 Jul;27(3):399-405. doi: 10.1016/0091-3057(87)90340-6.
Long term administration of the antipsychotic drugs thioridazine, trifluoperazine, haloperidol, and sulpiride increased body weight in rats. This effect was found to be sex dependent, that is, while female rats were prone to gain weight, male rats did not. Chlorpromazine and fluphenazine decreased body weight in male rats but did not affect females. The mechanism of body weight gain was investigated with sulpiride. A linear relationship between dose of sulpiride and body weight gain was found. Also, sulpiride increased caloric intake, and both actions were counteracted by bromocriptine, a specific D2 receptor agonist. These results confirm that antipsychotic drugs affect feeding and body weight and suggest that hyperphagia and body weight gain might be mediated by blockade of dopamine receptors of the D2 type.
长期给予抗精神病药物硫利达嗪、三氟拉嗪、氟哌啶醇和舒必利会使大鼠体重增加。发现这种效应存在性别差异，即雌性大鼠容易体重增加，而雄性大鼠则不然。氯丙嗪和氟奋乃静可使雄性大鼠体重减轻，但对雌性大鼠无影响。用舒必利对体重增加的机制进行了研究。发现舒必利剂量与体重增加之间存在线性关系。此外，舒必利增加热量摄入，而这两种作用都被特异性D2受体激动剂溴隐亭所抵消。这些结果证实抗精神病药物会影响进食和体重，并表明食欲亢进和体重增加可能是由D2型多巴胺受体的阻断介导的。
