Wang Guijun, Cheuk Sherwin, Williams Kristopher, Sharma Vibha, Dakessian Lousi, Thorton Zeus
Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA.
Carbohydr Res. 2006 May 1;341(6):705-16. doi: 10.1016/j.carres.2006.01.023. Epub 2006 Feb 17.
Self-assembly of small molecules is a useful strategy for forming functional supramolecular structures. Three new series of methyl alpha-D-glucopyranoside derivatives, including esters and carbamates, have been synthesized and characterized. Several of these compounds are excellent hydrogelators and formed interesting self-assembled network structures, including birefringent fibers and tubules. The gelation properties depend on the acyl chain length and the headgroup structures. Small molecule sugar-based hydrogelators have potential applications in drug delivery and enzyme immobilization.
小分子的自组装是形成功能性超分子结构的一种有用策略。已经合成并表征了三个新系列的α-D-甲基吡喃葡萄糖苷衍生物，包括酯类和氨基甲酸酯类。其中几种化合物是优异的水凝胶剂，并形成了有趣的自组装网络结构，包括双折射纤维和小管。凝胶化性质取决于酰基链长度和头基结构。基于小分子糖的水凝胶剂在药物递送和酶固定化方面具有潜在应用。
