Schrader Michael
Department of Cell Biology and Cell Pathology, University of Marburg, Robert-Koch Str. 6, 35037 Marburg, Germany.
Biochim Biophys Acta. 2006 May-Jun;1763(5-6):531-41. doi: 10.1016/j.bbamcr.2006.01.004. Epub 2006 Feb 2.
Mitochondria and peroxisomes are ubiquitous subcellular organelles, which are highly dynamic and display large plasticity. Recent studies have led to the surprising finding that both organelles share components of their division machinery, namely the dynamin-related protein DLP1/Drp1 and hFis1, which recruits DLP1/Drp1 to the organelle membranes. This review addresses the current state of knowledge concerning the dynamics and fission of peroxisomes, especially in relation to mitochondrial morphology and division in mammalian cells.
线粒体和过氧化物酶体是普遍存在的亚细胞器，它们高度动态且具有很大的可塑性。最近的研究有了一个惊人的发现，即这两种细胞器共享其分裂机制的组成部分，即动力蛋白相关蛋白DLP1/Drp1和hFis1，hFis1将DLP1/Drp1招募到细胞器膜上。本综述阐述了有关过氧化物酶体动态变化和分裂的当前知识状态，特别是与哺乳动物细胞中线粒体形态和分裂的关系。
