Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
J Cell Biol. 2023 Sep 4;222(9). doi: 10.1083/jcb.202304076. Epub 2023 Aug 2.
Organelle division and segregation are important in cellular homeostasis. Peroxisomes (POs) and mitochondria share a core division machinery and mechanism of membrane scission. The division of each organelle is interdependent not only on the other but also on other organelles, reflecting the dynamic communication between subcellular compartments, even as they coordinate the exchange of metabolites and signals. We highlight common and unique mechanisms involved in the fission of these organelles under the premise that much can be gleaned regarding the division of one organelle based on information available for the other.
细胞器的分裂和隔离对于细胞内稳态很重要。过氧化物酶体 (PO) 和线粒体共享核心分裂机制和膜分裂机制。每个细胞器的分裂不仅相互依赖，而且还依赖于其他细胞器，反映了亚细胞区室之间的动态通信，即使它们协调代谢物和信号的交换也是如此。我们在基于其他细胞器的可用信息可以了解一个细胞器的分裂的前提下，强调这些细胞器分裂所涉及的共同和独特的机制。
