Lake Aimee N, Bedford Mark T
The University of Texas MD Anderson Cancer Center, Science Park-Research Division, Smithville, TX 78957, USA.
Mutat Res. 2007 May 1;618(1-2):91-101. doi: 10.1016/j.mrfmmm.2006.09.010. Epub 2007 Jan 21.
DNA is under constant attack from intracellular and external mutagens. Sites of DNA damage need to be pinpointed so that the DNA repair machinery can be mobilized to the proper location. The identification of damaged sites, recruitment of repair factors, and assembly of repair "factories" is orchestrated by posttranslational modifications (PTMs). These PTMs include phosphorylation, ubiquitination, sumoylation, acetylation, and methylation. Here we discuss recent data surrounding the roles of arginine and lysine methylation in DNA repair processes.
DNA 不断受到细胞内和外部诱变剂的攻击。需要精确确定 DNA 损伤位点，以便将 DNA 修复机制动员到合适的位置。翻译后修饰（PTM）精心安排了损伤位点的识别、修复因子的募集以及修复“工厂”的组装。这些翻译后修饰包括磷酸化、泛素化、SUMO 化、乙酰化和甲基化。在这里，我们讨论围绕精氨酸和赖氨酸甲基化在 DNA 修复过程中作用的最新数据。
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