丙烯酰胺及其类似物的神经毒性以及这些类似物和其他药剂对丙烯酰胺神经病变的影响。
Neurotoxicity of acrylamide and its analogues and effects of these analogues and other agents on acrylamide neuropathy.
作者信息
Edwards P M
出版信息
Br J Ind Med. 1975 Feb;32(1):31-8. doi: 10.1136/oem.32.1.31.
Abstract
N-Hydroxymethylacrylamide, N-methylacrylamide, and N,N-diethylacrylamide produce peripheral neuropathy in rats. Seven other compounds related to acrylamide do not produce neuropathy. Rats given one of the three neurotoxic compounds are more susceptible to acrylamide. A regime for testing acrylamide analogues for neuro-toxicity is suggested. DDT, phenobarbitone, or high dietary concentrations of vitamin A or E have no effect on the development of acrylamide neuropathy in rats. Acrylamide produces neuropathy in hens but not in frogs or goldfish.
摘要
N-羟甲基丙烯酰胺、N-甲基丙烯酰胺和N,N-二乙基丙烯酰胺可使大鼠产生周围神经病变。其他七种与丙烯酰胺相关的化合物不会导致神经病变。给予三种神经毒性化合物之一的大鼠对丙烯酰胺更敏感。提出了一种测试丙烯酰胺类似物神经毒性的方案。滴滴涕、苯巴比妥或高膳食浓度的维生素A或E对大鼠丙烯酰胺神经病变的发展没有影响。丙烯酰胺可使母鸡产生神经病变，但对青蛙或金鱼则不然。
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