关于与丙烯酰胺相关的化合物对大鼠影响的观察报告。
Observations on the effects on rats of compounds related to acrylamide.
作者信息
Barnes J M
出版信息
Br J Ind Med. 1970 Apr;27(2):147-9. doi: 10.1136/oem.27.2.147.
Abstract
147-149. Nine compounds (Table), close chemical relations of acrylamide, were given to adult rats both in their diet and as repeated daily doses by mouth. Dose rates were such that with acrylamide acute poisoning and neuropathy would have resulted. Seven of the compounds were without effect. N-methylacrylamide and N-hydroxymethylacrylamide produced some neurotoxic effects in large doses. The presence of acrylamide as an impurity in the compound tested was not excluded.
摘要
147 - 149。将九种与丙烯酰胺有密切化学关系的化合物（见表）添加到成年大鼠的饮食中，并每日经口重复给药。给药剂量足以导致丙烯酰胺急性中毒和神经病变。其中七种化合物没有效果。N - 甲基丙烯酰胺和N - 羟甲基丙烯酰胺在大剂量时产生了一些神经毒性作用。不排除所测试的化合物中存在丙烯酰胺杂质。
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Six cases of acrylamide poisoning.6例丙烯酰胺中毒病例。
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Peripheral neuropathy in rats produced by acrylamide.丙烯酰胺所致大鼠周围神经病变
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