Rodríguez-Pérez José Manuel, Fragoso José Manuel, Alvarez-León Edith, Martínez-Rodríguez Nancy, Gallardo Guillermo J, Inés-Real Selene, Granados Julio, Reyes Pedro A, Vargas-Alarcón Gilberto
Department of Physiology, Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan 14080, Mexico City, Mexico.
Exp Mol Pathol. 2007 Feb;82(1):49-52. doi: 10.1016/j.yexmp.2006.10.002. Epub 2006 Nov 28.
The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 ethnically matched healthy controls using the polymerase chain reaction-sequence specific oligonucleotides (PCR-SSO) technique. IDC patients showed increased frequencies of HLA-DR4 (pC=0.02, OR=1.87), HLA-DQB10301 (pC=0.02, OR=1.92) and HLA-DQB10302 (pC=0.02, OR=1.87) when compared to healthy controls. On the other hand, IDC patients also showed decreased frequencies of HLA-DR11 allele (pC=0.03, OR=0.26) and HLA-DQB1*0201 (pC=0.04, OR=0.41). These data suggest that variation in class II HLA alleles could be a genetic factor involved in the susceptibility to IDC of the Mexican Mestizo population.
本研究的目的是评估II类主要组织相容性复合体（MHC）基因（HLA-DR和HLA-DQB）与墨西哥患者特发性扩张型心肌病（IDC）遗传易感性之间的关系。采用聚合酶链反应-序列特异性寡核苷酸（PCR-SSO）技术，对53例IDC患者和99例种族匹配的健康对照者的HLA-DR和DQB等位基因进行了分析。与健康对照者相比，IDC患者的HLA-DR4（pC=0.02，OR=1.87）、HLA-DQB10301（pC=0.02，OR=1.92）和HLA-DQB10302（pC=0.02，OR=1.87）频率增加。另一方面，IDC患者的HLA-DR11等位基因（pC=0.03，OR=0.26）和HLA-DQB1*0201（pC=0.04，OR=0.41）频率也降低。这些数据表明，II类HLA等位基因的变异可能是墨西哥梅斯蒂索人群IDC易感性的一个遗传因素。
