来自蘑菇干腐菌的漆斑菌素类似物及其自由基清除活性。
Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity.
作者信息
Lee In-Kyoung, Yun Bong-Sik
机构信息
Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-333, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2006 May 1;16(9):2376-9. doi: 10.1016/j.bmcl.2006.01.121. Epub 2006 Feb 20.
Three new free radical scavengers were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compound davallialactone. Their structures were established as hispidin analogs by extensive NMR spectral data. Compounds 3 and 4 displayed significant scavenging activity against the superoxide radical anion, ABTS radical cation, and DPPH radical, while 1 and 2 exhibited potent antioxidative activity only against ABTS radical cation.
从干腐菌（刺革菌科）子实体的甲醇提取物中分离出三种新的自由基清除剂，以及已知化合物骨碎补内酯。通过广泛的核磁共振光谱数据确定它们的结构为漆斑菌素类似物。化合物3和4对超氧阴离子自由基、ABTS阳离子自由基和DPPH自由基表现出显著的清除活性，而化合物1和2仅对ABTS阳离子自由基表现出较强的抗氧化活性。
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