随着衰老，多巴胺能神经元对鱼藤酮诱导的毒性的敏感性增强。
Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging.
作者信息
Phinney Amie L, Andringa Gerda, Bol John G J M, Wolters Erik Ch, van Muiswinkel Freek L, van Dam Anne-Marie W, Drukarch Benjamin
机构信息
Department of Medical Pharmacology, Institute for Clinical and Experimental Neurosciences, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
出版信息
Parkinsonism Relat Disord. 2006 May;12(4):228-38. doi: 10.1016/j.parkreldis.2005.12.002. Epub 2006 Feb 20.
Rotenone has been reported to induce various degrees of Parkinsonism in rats. We tested whether advancing age alters the sensitivity of dopaminergic neurons to rotenone. A low, systemic dose of rotenone had no effect on young rats, but led to a 20-30% reduction of tyrosine hydroxylase-positive neurons in the substantia nigra of older rats. The effect was specific to nigral dopaminergic neurons and may be associated with the increase of glial cell activation in older rats. These data suggest that age enhances the sensitivity of dopaminergic neurons to rotenone and should be considered when assessing models of Parkinson's disease.
据报道，鱼藤酮可在大鼠中诱发不同程度的帕金森症。我们测试了衰老是否会改变多巴胺能神经元对鱼藤酮的敏感性。低剂量全身性鱼藤酮对年轻大鼠没有影响，但会导致老年大鼠黑质中酪氨酸羟化酶阳性神经元减少20%-30%。这种效应是黑质多巴胺能神经元特有的，可能与老年大鼠中胶质细胞活化增加有关。这些数据表明，衰老会增强多巴胺能神经元对鱼藤酮的敏感性，在评估帕金森病模型时应予以考虑。
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