长期全身性接触农药会重现帕金森病的特征。

Chronic systemic pesticide exposure reproduces features of Parkinson's disease.

作者信息

Betarbet R, Sherer T B, MacKenzie G, Garcia-Osuna M, Panov A V, Greenamyre J T

机构信息

Department of Neurology, Emory University, 1639 Pierce Drive, WMB 6000, Atlanta, Georgia 30322, USA.

出版信息

Nat Neurosci. 2000 Dec;3(12):1301-6. doi: 10.1038/81834.

DOI:10.1038/81834

PMID:11100151

Abstract

The cause of Parkinson's disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other environmental toxins, and biochemical studies implicate a systemic defect in mitochondrial complex I. We report that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity. Nigral neurons in rotenone-treated rats accumulate fibrillar cytoplasmic inclusions that contain ubiquitin and alpha-synuclein. These results indicate that chronic exposure to a common pesticide can reproduce the anatomical, neurochemical, behavioral and neuropathological features of PD.

摘要

帕金森病（PD）的病因尚不清楚，但流行病学研究表明其与农药及其他环境毒素有关，生化研究则提示线粒体复合体I存在系统性缺陷。我们报告称，亲脂性农药鱼藤酮对复合体I进行慢性、全身性抑制，会导致高度选择性的黑质纹状体多巴胺能神经元变性，在行为上表现为运动迟缓及僵硬。经鱼藤酮处理的大鼠黑质神经元会积累含有泛素和α-突触核蛋白的纤维状胞质内含物。这些结果表明，长期接触一种常见农药可重现帕金森病的解剖学、神经化学、行为及神经病理学特征。