Ambros-Rudolph Christina M, Müllegger Robert R, Vaughan-Jones Samantha A, Kerl Helmut, Black Martin M
Department of Dermatology, Medical University Graz, Graz, Austria.
J Am Acad Dermatol. 2006 Mar;54(3):395-404. doi: 10.1016/j.jaad.2005.12.012.
We sought to evaluate the frequency and clinical characteristics of pruritic dermatoses in pregnancy and to assess a rationalized classification.
Data of 505 pregnant patients seen at two university-based dermatologic hospitals (1994-2004) were retrospectively studied.
Diagnoses included eczema in pregnancy (49.7%), polymorphic eruption of pregnancy (PEP) (21.6%), pemphigoid gestationis (PG) (4.2%), intrahepatic cholestasis of pregnancy (ICP) (3%), prurigo of pregnancy (0.8%), pruritic folliculitis of pregnancy (0.2%), and miscellaneous dermatoses (20.6%). Eczema in pregnancy, prurigo of pregnancy, and pruritic folliculitis of pregnancy showed considerable overlap and were summarized as atopic eruption of pregnancy (AEP). While PEP, PG, and ICP presented in late pregnancy, AEP started significantly earlier. Primigravidae and multiple gestations were characteristic for PEP, abdominal involvement for PEP and PG, and a history of affected pregnancies for ICP.
This was a retrospective study.
We propose classifying the dermatoses of pregnancy as PG, PEP, AEP, and ICP. Stereotypic immunofluorescence and laboratory findings are diagnostic of PG and ICP, whereas distinct clinical characteristics facilitate discrimination between PEP and AEP.
我们试图评估妊娠瘙痒性皮肤病的发病率及临床特征，并评估一种合理的分类方法。
对两所大学附属医院（1994 - 2004年）诊治的505例妊娠患者的数据进行回顾性研究。
诊断包括妊娠湿疹（49.7%）、妊娠多形性皮疹（PEP，21.6%）、妊娠类天疱疮（PG，4.2%）、妊娠肝内胆汁淤积症（ICP，3%）、妊娠痒疹（0.8%）、妊娠瘙痒性毛囊炎（0.2%）以及其他皮肤病（20.6%）。妊娠湿疹、妊娠痒疹和妊娠瘙痒性毛囊炎有相当程度的重叠，被归纳为妊娠特应性皮疹（AEP）。PEP、PG和ICP出现在妊娠晚期，而AEP发病明显更早。初产妇和多胎妊娠是PEP的特征，PEP和PG累及腹部，ICP有既往妊娠受累史。
这是一项回顾性研究。
我们建议将妊娠皮肤病分类为PG、PEP、AEP和ICP。典型的免疫荧光和实验室检查结果可诊断PG和ICP，而独特的临床特征有助于区分PEP和AEP。
