Ream Emma, Richardson Alison, Alexander-Dann Caroline
Florence Nightingale School of Nursing & Midwifery, King's College London, UK.
J Pain Symptom Manage. 2006 Feb;31(2):148-61. doi: 10.1016/j.jpainsymman.2005.07.003.
This study evaluated a supportive intervention for fatigue in patients undergoing chemotherapy. One hundred three chemotherapy-naïve patients were recruited, stratified by treatment regimen, and randomly allocated to intervention or usual care. The intervention was conducted over three months. Recipients were provided with an investigator-designed information pack and Fatigue Diary that they completed during the week following each treatment. Additionally, support nurses visited them monthly at home. They assessed fatigue, provided psychological support, and coached participants in self-care. The intervention group reported significantly less fatigue (P < 0.05), lower associated distress (P < 0.05), and less impact of fatigue on valued pastimes (P < 0.05) than the control group. Further, they reported significantly less anxiety (P < 0.05) and depression (P < 0.05) and displayed more adaptive coping (P < 0.05). The intervention enabled patients to adapt to living with fatigue and contributed to their psychological/emotional well-being and ability to cope with their illness and treatment.
本研究评估了一种针对化疗患者疲劳的支持性干预措施。招募了103名未接受过化疗的患者，根据治疗方案进行分层，并随机分配至干预组或常规护理组。干预持续三个月。为受试者提供了一份由研究者设计的信息包和疲劳日记，他们在每次治疗后的一周内完成填写。此外，支持护士每月上门探访他们。护士评估疲劳情况，提供心理支持，并指导参与者进行自我护理。与对照组相比，干预组报告的疲劳程度显著更低（P < 0.05），相关痛苦程度更低（P < 0.05），疲劳对重要消遣活动的影响更小（P < 0.05）。此外，他们报告的焦虑（P < 0.05）和抑郁（P < 0.05）程度显著更低，且表现出更多适应性应对方式（P < 0.05）。该干预措施使患者能够适应与疲劳共存的生活，并有助于他们的心理/情绪健康以及应对疾病和治疗的能力。
