Kuklinski B, Buchner M, Schweder R, Nagel R
Abteilung für Anästhesiologie und Intensivmedizin, Klinikums Rostock Süd.
Z Gesamte Inn Med. 1991 Apr;46(5):145-9.
Malonic dialdehyde as an indirect marker of the lipid peroxidation was found increased in the acute pancreatitis compared with persons of the same age and sex. Its concentrations inversely correlated to those of the serum calcium during the course of the disease and additionally they proved to be indicator of the prognosis. Postulating that the acute pancreatitis must be a "free radical disease", in a randomized clinical study the adjuvant therapy of the acute necrotizing pancreatitis (n = 8) with sodium selenite was carried out in a daily dose of 500 micrograms. The lethality of the control group was 89% (8 out of altogether 9 patients), no patient died in the therapy group. By the selenium therapy within 24 hours a normalization of the serum calcium and a decrease of the increased MDA-values could be achieved. It was concluded that by selenium increased activities of the phospholipid-hydroperoxide-glutathione peroxidase were induced, by means of which a peroxidation protection of membrane fatty acids, an inhibition of the activity of phospholipase A2 and an interruption of the arachidonic acid cascade must have been reached.
与同年龄、同性别的人相比，丙二醛作为脂质过氧化的间接标志物在急性胰腺炎患者中升高。在疾病过程中，其浓度与血清钙浓度呈负相关，此外，它们被证明是预后的指标。假设急性胰腺炎一定是一种“自由基疾病”，在一项随机临床研究中，对8例急性坏死性胰腺炎患者进行了亚硒酸钠辅助治疗，日剂量为500微克。对照组的死亡率为89%（9例患者中有8例死亡），治疗组无患者死亡。通过硒治疗，24小时内可使血清钙恢复正常，并降低升高的丙二醛值。得出的结论是，硒可诱导磷脂氢过氧化物谷胱甘肽过氧化物酶活性增加，通过这种方式，必定实现了对膜脂肪酸的过氧化保护、磷脂酶A2活性的抑制以及花生四烯酸级联反应的中断。
