机械敏感性与眼睛：应对压力的细胞
Mechanosensitivity and the eye: cells coping with the pressure.
作者信息
Tan J C H, Kalapesi F B, Coroneo M T
机构信息
Department of Ophthalmology, Prince of Wales Hospital, High Street, Randwick, NSW 2032, Australia.
出版信息
Br J Ophthalmol. 2006 Mar;90(3):383-8. doi: 10.1136/bjo.2005.079905.
Abstract
The cells of the various organ systems in humans are subject to mechanical forces to which they must respond. Here the authors review what is known of the ways in which the cells of animals, ranging from the prokaryotic to humans, sense and transduce mechanical forces to respond to such stimuli. In what way this pertains to the eye, especially with respect to axial myopia and the pressure related disease of glaucoma, is then surveyed.
摘要
人类各种器官系统的细胞会受到机械力作用，它们必须对此作出反应。在此，作者回顾了从原核生物到人类等各类动物细胞感知和转换机械力以应对此类刺激的已知方式。随后探讨了这与眼睛的关系，特别是在轴性近视和青光眼等与压力相关疾病方面的关系。
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本文引用的文献
1
Differential expression of the human chloride channel genes in the trabecular meshwork under stress conditions.应激条件下人小梁网中氯离子通道基因的差异表达。
Exp Eye Res. 2005 Jun;80(6):801-13. doi: 10.1016/j.exer.2004.12.009.
2
Inhibition of swelling-activated Cl- currents by functional anti-ClC-3 antibody in native bovine non-pigmented ciliary epithelial cells.功能性抗ClC-3抗体对天然牛非色素睫状上皮细胞中肿胀激活的氯离子电流的抑制作用。
Invest Ophthalmol Vis Sci. 2005 Mar;46(3):948-55. doi: 10.1167/iovs.04-1004.
3
Functional and molecular characterization of a volume-activated chloride channel in rabbit corneal epithelial cells.兔角膜上皮细胞中容积激活氯通道的功能与分子特征
J Membr Biol. 2004 Sep 1;201(1):41-9. doi: 10.1007/s00232-004-0706-5.
4
Modulation of aqueous humor outflow by ionic mechanisms involved in trabecular meshwork cell volume regulation.小梁网细胞体积调节中涉及的离子机制对房水流出的调节作用。
Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3650-61. doi: 10.1167/iovs.04-0060.
5
Pressure-induced changes in axial eye length of chick and tree shrew: significance of myofibroblasts in the sclera.
Invest Ophthalmol Vis Sci. 2004 Mar;45(3):758-63. doi: 10.1167/iovs.03-0732.
6
Depolarization of sensory terminals and the initiation of impulses in the muscle spindle.感觉末梢的去极化以及肌梭中冲动的起始。
J Physiol. 1950 Oct 16;111(3-4):261-82. doi: 10.1113/jphysiol.1950.sp004479.
7
Changes in gene expression in response to mechanical strain in human scleral fibroblasts.人巩膜成纤维细胞中基因表达对机械应变的响应变化
Exp Eye Res. 2004 Feb;78(2):275-84. doi: 10.1016/j.exer.2003.10.007.
8
Cell volume response to hyposmotic shock and elevated cAMP in bovine trabecular meshwork cells.牛眼小梁网细胞对低渗休克和cAMP升高的细胞体积反应
Exp Eye Res. 2004 Jan;78(1):15-26. doi: 10.1016/j.exer.2003.10.001.
9
Signaling pathways used in trabecular matrix metalloproteinase response to mechanical stretch.小梁基质金属蛋白酶对机械拉伸反应中所使用的信号通路。
Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5174-81. doi: 10.1167/iovs.03-0213.
10
The generation of electric activity in a nerve ending.
Ann N Y Acad Sci. 1959 Aug 28;81:367-87. doi: 10.1111/j.1749-6632.1959.tb49320.x.
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