Umeki S, Hashiguchi K, Okimoto N, Soejima R
Department of Medicine, Kawasaki Medical School.
Arerugi. 1991 Feb;40(2):126-31.
Regarding 249 bronchial asthma patients having been admitted to our division for the recent 9 years, clinical manifestations of 8 bronchial asthma with primary lung cancer (group A; squamous cell carcinoma--5 cases, adenocarcinoma--2 cases, small cell carcinoma--1 case; 3.2% of 249 cases) and 8 asthma patients with extrathoracic malignancy (group B; gastric cancer--3 cases, malignant lymphoma--2 cases, bladder cancer--1 case, laryngeal cancer--1 case, prostatic cancer--1 case) were investigated. In group A, the mean of asthmatic history was 19 years and all cases were associated with respiratory tract infections. Three of 8 patients, were mild type and other 5 were moderate type. In group B, the mean of asthmatic history was 20 years and all cases were involved with respiratory tract infections. Five of 8 patients were mild type and other 3 were moderate type. The mean smoking (Brinkmann) index (1194) in group A was significantly higher than that (166) in 241 asthmatic patients without lung cancer or that (169) in group B. The median survival duration (more than 26 months) of group A patients was significantly lower than that (more than 77 months) of group B. These results suggested that, in many bronchial asthma patients accompanied by primary lung cancer who have adult-typed infectious asthmatic history, smoking exposure and aging are deeply related to the development of lung cancer.
对近9年我院收治的249例支气管哮喘患者，调查了8例合并原发性肺癌的支气管哮喘患者（A组；鳞状细胞癌5例，腺癌2例，小细胞癌1例；占249例的3.2%）及8例合并胸外恶性肿瘤的哮喘患者（B组；胃癌3例，恶性淋巴瘤2例，膀胱癌1例，喉癌1例，前列腺癌1例）的临床表现。A组哮喘病史平均19年，所有病例均合并呼吸道感染。8例患者中3例为轻度，5例为中度。B组哮喘病史平均20年，所有病例均合并呼吸道感染。8例患者中5例为轻度，3例为中度。A组平均吸烟（布林克曼）指数（1194）显著高于241例无肺癌的哮喘患者（166）及B组（169）。A组患者的中位生存时间（超过26个月）显著低于B组（超过77个月）。这些结果提示，在许多伴有原发性肺癌的支气管哮喘患者中，有成人型感染性哮喘病史，吸烟暴露和衰老与肺癌的发生密切相关。
