[合并慢性阻塞性肺疾病的肺癌的临床及病理特征]

[Clinical and pathological characteristics of lung cancer with chronic obstructive pulmonary disease].

作者信息

Miyamoto H, Hiraga T, Kishi F, Isobe H, Shimizu T, Haneda H, Kawakami Y

机构信息

First Department of Internal Medicine, Hokkaido University, Sapporo, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1990 May;28(5):736-40.

PMID:2170729

Abstract

Forty-two lung cancer patients with COPD (7.9% of 534 lung cancers), and 84 age- and sex-ratio-matched controls who were randomly selected from lung cancer patients without COPD were examined. Lung cancers with COPD consisted of 25 cases of squamous call carcinoma (59.5%), 11 of adenocarcinoma (26.2%), 2 of small-cell carcinoma (4.8%), and 4 of large-cell carcinoma (9.5%). Squamous cell carcinoma occurred more in patients with COPD than in controls (35.7%) (p less than 0.01). In squamous cell tumors with COPD, 12 cases (48.0%) were centrally located and 13 cases (52.0%) were peripherally located. Squamous cell carcinoma of peripheral origin occurred more in patients with predominant emphysema (76.9%) than controls (36.7%) (p less than 0.05). Our results suggest that the COPD patients with predominant emphysema may be at greater risk for squamous cell tumors of peripheral origin.

摘要

对42例合并慢性阻塞性肺疾病（COPD）的肺癌患者（占534例肺癌患者的7.9%）以及从无COPD的肺癌患者中随机选取的84例年龄和性别比例匹配的对照者进行了检查。合并COPD的肺癌患者中，有25例鳞状细胞癌（59.5%）、11例腺癌（26.2%）、2例小细胞癌（4.8%）和4例大细胞癌（9.5%）。COPD患者中鳞状细胞癌的发生率高于对照组（35.7%）（p<0.01）。在合并COPD的鳞状细胞肿瘤中，12例（48.0%）为中央型，13例（52.0%）为周围型。以肺气肿为主的患者中周围型鳞状细胞癌的发生率高于对照组（76.9%比36.7%）（p<0.05）。我们的结果表明，以肺气肿为主的COPD患者发生周围型鳞状细胞肿瘤的风险可能更高。