• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Two- and three-locus tests for linkage analysis using recombinant inbred lines.使用重组近交系进行连锁分析的双位点和三位点测试。
Genetics. 2006 May;173(1):451-9. doi: 10.1534/genetics.105.047175. Epub 2006 Feb 19.
2
IRILmap: linkage map distance correction for intermated recombinant inbred lines/advanced recombinant inbred strains.IRILmap：用于互交重组自交系/高级重组自交系的连锁图谱距离校正
Bioinformatics. 2005 Aug 15;21(16):3441-2. doi: 10.1093/bioinformatics/bti543. Epub 2005 Jun 16.
3
Detection of quantitative trait Loci influencing recombination using recombinant inbred lines.利用重组自交系检测影响重组的数量性状位点。
Genetics. 2007 Dec;177(4):2309-19. doi: 10.1534/genetics.107.076679. Epub 2007 Oct 18.
4
Recombination fraction in pre-recombinant inbred lines (PRERIL) - revisiting a century old problem in genetics.重组分数在预重组近交系（PRERIL）中的作用-重访遗传学中一个百年老问题。
BMC Genomics. 2024 Sep 2;25(1):822. doi: 10.1186/s12864-024-10699-z.
5
On the determination of recombination rates in intermated recombinant inbred populations.关于在杂交重组近交群体中重组率的测定
Genetics. 2003 Jun;164(2):741-5. doi: 10.1093/genetics/164.2.741.
6
Identification of quantitative trait loci across recombinant inbred lines and testcross populations for traits of agronomic importance in rice.水稻重要农艺性状在重组自交系和测交群体中的数量性状基因座鉴定。
Genetics. 2006 Feb;172(2):1287-300. doi: 10.1534/genetics.105.047209. Epub 2005 Dec 1.
7
Design and construction of recombinant inbred lines.重组自交系的设计与构建。
Methods Mol Biol. 2012;871:31-9. doi: 10.1007/978-1-61779-785-9_3.
8
Development of a near-isogenic line population of Arabidopsis thaliana and comparison of mapping power with a recombinant inbred line population.拟南芥近等基因系群体的构建及其与重组自交系群体作图能力的比较。
Genetics. 2007 Feb;175(2):891-905. doi: 10.1534/genetics.106.066423. Epub 2006 Dec 18.
9
Quantitative trait loci mapping in five new large recombinant inbred line populations of Arabidopsis thaliana genotyped with consensus single-nucleotide polymorphism markers.利用共有单核苷酸多态性标记对五个新的大型拟南芥重组自交系群体进行数量性状基因座定位。
Genetics. 2008 Apr;178(4):2253-64. doi: 10.1534/genetics.107.083899.
10
The genomes of recombinant inbred lines.重组自交系的基因组。
Genetics. 2005 Feb;169(2):1133-46. doi: 10.1534/genetics.104.035212. Epub 2004 Nov 15.

引用本文的文献

1
Genetic Architecture of a Rice Nested Association Mapping Population.一个水稻巢式关联作图群体的遗传结构
G3 (Bethesda). 2017 Jun 7;7(6):1913-1926. doi: 10.1534/g3.117.041608.
2
Signatures of Dobzhansky-Muller Incompatibilities in the Genomes of Recombinant Inbred Lines.重组自交系基因组中多布赞斯基-穆勒不相容性的特征
Genetics. 2016 Feb;202(2):825-41. doi: 10.1534/genetics.115.179473. Epub 2015 Dec 17.
3
QTL for seed protein and amino acids in the Benning × Danbaekkong soybean population.大豆 Benning×Danbaekkong 群体种子蛋白和氨基酸的 QTL 分析。
Theor Appl Genet. 2015 May;128(5):839-50. doi: 10.1007/s00122-015-2474-4. Epub 2015 Feb 12.
4
Characterizing uncertainty in high-density maps from multiparental populations.表征多亲群体高密度图谱中的不确定性。
Genetics. 2014 Sep;198(1):117-28. doi: 10.1534/genetics.114.167577.
5
Distribution of parental genome blocks in recombinant inbred lines.重组近交系中亲本基因组块的分布。
Genetics. 2011 Oct;189(2):645-54. doi: 10.1534/genetics.111.129700. Epub 2011 Aug 11.
6
Linkage analysis in unconventional mating designs in line crosses.在直线杂交的非常规交配设计中进行连锁分析。
Theor Appl Genet. 2011 Oct;123(6):897-906. doi: 10.1007/s00122-011-1635-3. Epub 2011 Jun 18.
7
Combining DNA pooling with selective recombinant genotyping for increased efficiency in fine mapping.结合 DNA 池与选择性重组基因分型提高精细定位效率。
Theor Appl Genet. 2010 Feb;120(4):775-83. doi: 10.1007/s00122-009-1198-8. Epub 2009 Nov 8.
8
Detailed recombination studies along chromosome 3B provide new insights on crossover distribution in wheat (Triticum aestivum L.).沿着3B染色体进行的详细重组研究为小麦（普通小麦）的交叉分布提供了新的见解。
Genetics. 2009 Feb;181(2):393-403. doi: 10.1534/genetics.108.097469. Epub 2008 Dec 8.
9
Precision of recombination frequency estimates after random intermating with finite population sizes.在有限种群规模下随机杂交后重组频率估计的精度。
Genetics. 2008 Jan;178(1):597-600. doi: 10.1534/genetics.107.078956.
10
Resistance to Colletotrichum lindemuthianum in Phaseolus vulgaris: a case study for mapping two independent genes.菜豆对菜豆炭疽病菌的抗性：两个独立基因定位的案例研究
Theor Appl Genet. 2008 Feb;116(3):407-15. doi: 10.1007/s00122-007-0678-y. Epub 2007 Dec 4.

本文引用的文献

1
Inbreeding and Linkage.近亲繁殖与连锁
Genetics. 1931 Jul;16(4):357-74. doi: 10.1093/genetics/16.4.357.
2
Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations.利用重组近交系间杂交进行数量性状基因座分析：理论与实证考量
Genetics. 2005 Jul;170(3):1299-311. doi: 10.1534/genetics.104.035709. Epub 2005 May 6.
3
The map expansion obtained with recombinant inbred strains and intermated recombinant inbred populations for finite generation designs.利用重组自交系和有限世代设计的互交重组自交群体获得的图谱扩展。
Genetics. 2005 Jun;170(2):875-9. doi: 10.1534/genetics.104.038026. Epub 2005 Mar 21.
4
The genomes of recombinant inbred lines.重组自交系的基因组。
Genetics. 2005 Feb;169(2):1133-46. doi: 10.1534/genetics.104.035212. Epub 2004 Nov 15.
5
The Collaborative Cross, a community resource for the genetic analysis of complex traits.协作杂交系，一种用于复杂性状遗传分析的群体资源。
Nat Genet. 2004 Nov;36(11):1133-7. doi: 10.1038/ng1104-1133.
6
WebQTL: web-based complex trait analysis.WebQTL：基于网络的复杂性状分析。
Neuroinformatics. 2003;1(4):299-308. doi: 10.1385/NI:1:4:299.
7
On the determination of recombination rates in intermated recombinant inbred populations.关于在杂交重组近交群体中重组率的测定
Genetics. 2003 Jun;164(2):741-5. doi: 10.1093/genetics/164.2.741.
8
Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort.复杂性状和数量性状的遗传剖析：通过群体努力从幻想变为现实。
Mamm Genome. 2002 Apr;13(4):175-8. doi: 10.1007/s00335-001-4001-Y.
9
Map Manager QTX, cross-platform software for genetic mapping.Map Manager QTX，用于基因定位的跨平台软件。
Mamm Genome. 2001 Dec;12(12):930-2. doi: 10.1007/s00335-001-1016-3.
10
MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations.MAPMAKER：一个用于构建实验群体和自然群体初级遗传连锁图谱的交互式计算机程序包。
Genomics. 1987 Oct;1(2):174-81. doi: 10.1016/0888-7543(87)90010-3.

使用重组近交系进行连锁分析的双位点和三位点测试。

Two- and three-locus tests for linkage analysis using recombinant inbred lines.

作者信息

Martin Olivier C, Hospital Frédéric

机构信息

INRA, UMR de Génétique Végétale, Ferme du Moulon, 91190 Gif-sur-Yvette, France.

出版信息

Genetics. 2006 May;173(1):451-9. doi: 10.1534/genetics.105.047175. Epub 2006 Feb 19.

DOI:10.1534/genetics.105.047175
PMID:16489236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1461428/
Abstract

We consider fixed recombinant inbred lines (RILs) derived either by selfing or by full-sib mating; when applicable, we also consider intermated recombinant inbreds (IRIs). First, we show that the usual estimate of recombination fraction based on RIL data is biased, and we provide an estimate where the major part of that bias is removed. Second, we derive simple formulas to compute the frequencies of genotypes at three loci in RILs. We describe the nonindependence of multiple recombinations arising in RIL recombination data even though there may be no interference in each meiosis. Finally, we give formulas for interference tests, gene mapping, or QTL detection in RIL populations.

摘要

我们考虑通过自交或全同胞交配产生的固定重组近交系（RILs）；在适用的情况下，我们也考虑互交重组近交系（IRIs）。首先，我们表明基于RIL数据对重组率的常规估计存在偏差，并且我们提供了一种估计方法，其中大部分偏差被消除。其次，我们推导了计算RILs中三个位点基因型频率的简单公式。我们描述了RIL重组数据中出现的多重重组的非独立性，即使在每个减数分裂中可能不存在干涉。最后，我们给出了RIL群体中干涉检验、基因定位或QTL检测的公式。