Broman Karl W
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205-2179, USA.
Genetics. 2005 Feb;169(2):1133-46. doi: 10.1534/genetics.104.035212. Epub 2004 Nov 15.
Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable community resource. The use of such eight-way RILs will require a detailed understanding of the relationship between alleles at linked loci on an RI chromosome. We extend the work of Haldane and Waddington on two-way RILs and describe the map expansion, clustering of breakpoints, and other features of the genomes of multiple-strain RILs as a function of the level of crossover interference in meiosis.
重组近交系（RILs）可作为强大的遗传作图工具。最近，复杂性状联盟的成员提议在小鼠中开发一组大型的八系重组近交系，其源自八个遗传背景不同的亲本菌株。这样一组将是宝贵的社区资源。使用这种八系重组近交系将需要详细了解重组近交系染色体上连锁位点等位基因之间的关系。我们扩展了霍尔丹和沃丁顿关于双系重组近交系的工作，并描述了多菌株重组近交系基因组的图谱扩展、断点聚类以及其他特征，这些特征是减数分裂中交叉干扰水平的函数。
