神经降压素与促肾上腺皮质激素对 dexamethasone 抑制大鼠垂体 - 肾上腺皮质轴作用的比较。

Comparison of the effects of neurotensin and ACTH on the pituitary-adrenocortical axis of dexamethasone-suppressed rats.

作者信息

Malendowicz L K, Nussdorfer G G, Lesniewska B, Markowska A, Nowak M

机构信息

Department of Histology and Embryology, Poznan Academy of Medicine, Poland.

出版信息

J Steroid Biochem Mol Biol. 1991 Jul;39(1):115-7. doi: 10.1016/0960-0760(91)90019-2.

DOI:10.1016/0960-0760(91)90019-2

PMID:1648950

Abstract

Neurotensin (NT) (12-48 micrograms/kg-1/day-1, for 2 days, s.c.), like ACTH (60 micrograms/kg-1/day-1, for 2 days, s.c.), counteracted the dexamethasone (Dx)-induced (120 micrograms/kg-1/day-1, for 4 days, s.c.) adrenal zona-fasciculata cell atrophy. NT notably raised, in Dx-suppressed rats, the plasma concentration of ACTH, which reached about that found after exogenous ACTH administration. However, at variance with ACTH, NT did not enhance either plasma corticosterone (B) level or B production by adrenal quarters in vitro. The conclusion is drawn that NT modulates the function of the rat pituitary-adrenocortical axis, by simultaneously stimulating hypophyseal ACTH release and inhibiting steroidogenesis at the adrenal level.

摘要

神经降压素（NT）（12 - 48微克/千克-1/天-1，皮下注射，共2天），与促肾上腺皮质激素（ACTH）（60微克/千克-1/天-1，皮下注射，共2天）一样，可对抗地塞米松（Dx）诱导（120微克/千克-1/天-1，皮下注射，共4天）的肾上腺束状带细胞萎缩。在Dx抑制的大鼠中，NT显著提高了促肾上腺皮质激素的血浆浓度，该浓度达到了外源性给予促肾上腺皮质激素后所发现的水平。然而，与促肾上腺皮质激素不同的是，NT既没有提高血浆皮质酮（B）水平，也没有增强体外培养的肾上腺组织块的B生成。得出的结论是，NT通过同时刺激垂体促肾上腺皮质激素释放和抑制肾上腺水平的类固醇生成来调节大鼠垂体 - 肾上腺皮质轴的功能。