神经降压素对大鼠垂体 - 肾上腺皮质功能的调节作用：急性剂量依赖性双相效应的证据。

Modulatory action of neurotensin on the pituitary-adrenocortical function in rats: evidence for an acute dose-dependent biphasic effect.

作者信息

Malendowicz L K, Nussdorfer G G

机构信息

Department of Histology and Embriology, School of Medicine, Poznan, Poland.

出版信息

Life Sci. 1994;55(3):201-5. doi: 10.1016/0024-3205(94)00880-9.

DOI:10.1016/0024-3205(94)00880-9

PMID:8007762

Abstract

Adult female rats were sc injected with 0.6 or 1.2 nmol/100 g body wt of neurotensin (NT); control animals received a sc injection of saline vehicle. The plasma concentrations of ACTH, aldosterone and corticosterone were measured 1, 2 or 4 h after the injection. Our RIA estimates revealed that the lower dose of NT exerted a net stimulatory effect on the rat pituitary-adrenocortical function, that can be ascribed to the well-known NT-evoked enhancement of CRH release. Conversely, the higher dose of NT appeared to have a marked inhibitory effect on both pituitary ACTH release and adrenocortical secretion. The mechanism underlying this last action of NT remains to be elucidated.

摘要

成年雌性大鼠皮下注射0.6或1.2 nmol/100 g体重的神经降压素（NT）；对照动物皮下注射生理盐水。注射后1、2或4小时测量促肾上腺皮质激素（ACTH）、醛固酮和皮质酮的血浆浓度。我们的放射免疫分析估计显示，较低剂量的NT对大鼠垂体-肾上腺皮质功能产生净刺激作用，这可归因于众所周知的NT诱发的促肾上腺皮质激素释放激素（CRH）释放增强。相反，较高剂量的NT似乎对垂体ACTH释放和肾上腺皮质分泌均有明显抑制作用。NT这一最终作用的潜在机制仍有待阐明。