Gasper-Smith N, Singh S, Bost K L
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA.
Arch Virol. 2006 Jul;151(7):1423-9. doi: 10.1007/s00705-006-0725-z. Epub 2006 Feb 20.
Murine gammaherpesvirus 68 (gammaHV-68) was found to induce IL-6 secretion following in vitro infection of macrophages, but not cultured dendritic or epithelial cells. A detectable, but very limited IL-6 response was observed in the lungs and mediastinal lymph nodes following intranasal infection. Surprisingly, no detectable in vivo IL-6 production was observed in the spleen or sera of infected mice despite observable systemic leukocytosis. These studies demonstrate that endogenous IL-6 production contributes little to the host response, or to the viral-induced mononucleosis-like disease, due to the fact that limiting amounts of this cytokine are produced in vivo during gammaHV-68 infection.
鼠γ疱疹病毒68（γHV - 68）在体外感染巨噬细胞后可诱导白细胞介素6（IL - 6）分泌，但对培养的树突状细胞或上皮细胞则无此作用。鼻内感染后，在肺部和纵隔淋巴结中观察到可检测到但非常有限的IL - 6反应。令人惊讶的是，尽管观察到全身性白细胞增多，但在感染小鼠的脾脏或血清中未观察到可检测到的体内IL - 6产生。这些研究表明，内源性IL - 6产生对宿主反应或病毒诱导的单核细胞增多症样疾病贡献很小，因为在γHV - 68感染期间体内产生的这种细胞因子数量有限。
